Wednesday, June 15, 2011
Blood Pressure Best Indicator for Disease Uric Acid from Fructose High BP
Friday, July 30, 2010
Vitamin D Best Nonscientific Column About Why It is a Miracle Hormone
Although this article came very late, it is one of two best popular write-ups of the need for vitamin D I have read. She quotes Holick of Boston University who has been working on vitamin D for a longtime, but was virtually ignored by medical establishment and the exalted journals.
Shows how highly intelligent experts maintain their previous beliefs just like radicals on the Left and Right in spite of evidence contradicting their views. Long held beliefs are reinforced by repetition in our neurons and synapses and can’t be dislodged by making a logical fact filled argument. Stop try President Obama and play to your base which should include Independents.
We should all admit that experts do not always offer good advice and sometimes they lie if paid enough as we have seen in doctors supporting the approval of very dangerous medicines or supporting a drug even though many get sick and die. We should all also admit that we are more ignorant than we should be to make good decisions, but we rely on the garbage in garbage out philosophy without knowing we are spewing garbage.
Religion and other beliefs are entrenched in our neurons and synapses and even in our epigenetic genes which can be turned off or on by our environment whether physical or mental to help us survive and maintain our predilections which can be carried from one generation to another even when they are no longer appropriate.
Please read the whole article. Well worth while.
Jim Kawakami, July 30, 2010, http://jimboguy.blogspot.com
Vitamin D Best Nonscientific Column About Why It is a Miracle Hormone
NY Times Jane Brody, July 28, 2010, http://www.nytimes.com/2010/07/27/health/27brod.html?src=me&ref=homepage
Vitamin D promises to be the most talked-about and written-about supplement of the decade. While studies continue to refine optimal blood levels and recommended dietary amounts, the fact remains that a huge part of the population — from robust newborns to the frail elderly, and many others in between — are deficient in this essential nutrient.
If the findings of existing clinical trials hold up in future research, the potential consequences of this deficiency are likely to go far beyond inadequate bone development and excessive bone loss that can result in falls and fractures. Every tissue in the body, including the brain, heart, muscles and immune system, has receptors for vitamin D, meaning that this nutrient is needed at proper levels for these tissues to function well.
Studies indicate that the effects of a vitamin D deficiency include an elevated risk of developing (and dying from) cancers of the colon, breast and prostate; high blood pressure and cardiovascular disease; osteoarthritis; and immune-system abnormalities that can result in infections and autoimmune disorders like multiple sclerosis, Type 1 diabetes and rheumatoid arthritis.
Most people in the modern world have lifestyles that prevent them from acquiring the levels of vitamin D that evolution intended us to have. The sun’s ultraviolet-B rays absorbed through the skin are the body’s main source of this nutrient. Early humans evolved near the equator, where sun exposure is intense year round, and minimally clothed people spent most of the day outdoors.
“As a species, we do not get as much sun exposure as we used to, and dietary sources of vitamin D are minimal,” Dr. Edward Giovannucci, nutrition researcher at the Harvard School of Public Health, wrote in The Archives of Internal Medicine. Previtamin D forms in sun-exposed skin, and 10 to 15 percent of the previtamin is immediately converted to vitamin D, the form found in supplements. Vitamin D, in turn, is changed in the liver to 25-hydroxyvitamin D, the main circulating form. Finally, the kidneys convert 25-hydroxyvitamin D into the nutrient’s biologically active form, 1,25-dihydroxyvitamin D, also known as vitamin D hormone.
A person’s vitamin D level is measured in the blood as 25-hydroxyvitamin D, considered the best indicator of sufficiency. A recent study showed that maximum bone density is achieved when the blood serum level of 25-hydroxyvitamin D reaches 40 nanograms per milliliter or more.
“Throughout most of human evolution,” Dr. Giovannucci wrote, “when the vitamin D system was developing, the ‘natural’ level of 25-hydroxyvitamin D was probably around 50 nanograms per milliliter or higher. In modern societies, few people attain such high levels.”
A Common Deficiency
Although more foods today are supplemented with vitamin D, experts say it is rarely possible to consume adequate amounts through foods. The main dietary sources are wild-caught oily fish (salmon, mackerel, bluefish, and canned tuna) and fortified milk and baby formula, cereal and orange juice.
People in colder regions form their year’s supply of natural vitamin D in summer, when ultraviolet-B rays are most direct. But the less sun exposure, the darker a person’s skin and the more sunscreen used, the less previtamin D is formed and the lower the serum levels of the vitamin. People who are sun-phobic, babies who are exclusively breast-fed, the elderly and those living in nursing homes are particularly at risk of a serious vitamin D deficiency.
Dr. Michael Holick of Boston University, a leading expert on vitamin D and author of “The Vitamin D Solution” (Hudson Street Press, 2010), said in an interview, “We want everyone to be above 30 nanograms per milliliter, but currently in the United States, Caucasians average 18 to 22 nanograms and African-Americans average 13 to 15 nanograms.” African-American women are 10 times as likely to have levels at or below 15 nanograms as white women, the third National Health and Nutrition Examination Survey found.
Such low levels could account for the high incidence of several chronic diseases in this country, Dr. Holick maintains. For example, he said, in the Northeast, where sun exposure is reduced and vitamin D levels consequently are lower, cancer rates are higher than in the South. Likewise, rates of high blood pressure, heart disease, and prostate cancer are higher among dark-skinned Americans than among whites.
The rising incidence of Type 1 diabetes may be due, in part, to the current practice of protecting the young from sun exposure. When newborn infants in Finland were given 2,000 international units a day, Type 1 diabetes fell by 88 percent, Dr. Holick said.
The current recommended intake of vitamin D, established by the Institute of Medicine, is 200 I.U. a day from birth to age 50 (including pregnant women); 400 for adults aged 50 to 70; and 600 for those older than 70. While a revision upward of these amounts is in the works, most experts expect it will err on the low side. Dr. Holick, among others, recommends a daily supplement of 1,000 to 2,000 units for all sun-deprived individuals, pregnant and lactating women, and adults older than 50. The American Academy of Pediatrics recommends that breast-fed infants receive a daily supplement of 400 units until they are weaned and consuming a quart or more each day of fortified milk or formula.
Given appropriate sun exposure in summer, it is possible to meet the body’s yearlong need for vitamin D. But so many factors influence the rate of vitamin D formation in skin that it is difficult to establish a universal public health recommendation. Asked for a general recommendation, Dr. Holick suggests going outside in summer unprotected by sunscreen (except for the face, which should always be protected) wearing minimal clothing from 10 a.m. to 3 p.m. two or three times a week for 5 to 10 minutes.
Slathering skin with sunscreen with an SPF of 30 will reduce exposure to ultraviolet-B rays by 95 to 98 percent. But if you make enough vitamin D in your skin in summer, it can meet the body’s needs for the rest of the year, Dr. Holick said.
Can You Get Too Much?
If acquired naturally through skin, the body’s supply of vitamin D has a built-in cutoff. When enough is made, further exposure to sunlight will destroy any excess. Not so when the source is an ingested supplement, which goes directly to the liver.
Symptoms of vitamin D toxicity include nausea, vomiting, poor appetite, constipation, weakness and weight loss, as well as dangerous amounts of calcium that can result in kidney stones, confusion and abnormal heart rhythms.
But both Dr. Giovannucci and Dr. Holick say it is very hard to reach such toxic levels. Healthy adults have taken 10,000 I.U. a day for six months or longer with no adverse effects. People with a serious vitamin D deficiency are often prescribed weekly doses of 50,000 units until the problem is corrected. To minimize the risk of any long-term toxicity, these experts recommend that adults take a daily supplement of 1,000 to 2,000 units.
This article has been revised to reflect the following correction:
Correction: July 29, 2010 The Personal Health column on Tuesday, about the deficiency of vitamin D in much of the population, referred imprecisely to the publisher of a book by Dr. Michael Holick of Boston University, who said low levels of the vitamin could be contributing to high rates of some chronic diseases. While Penguin did not publish Dr. Holick’s book, “The Vitamin D Solution,” it owns the imprint that did, Hudson Street Press.
Monday, June 28, 2010
Vitamin D: Financial Times: Why governments are not acting on vitamin D
More from Reportage - Nov-24
In recent years, vitamin D has been going to some exciting places. Reports of new and promising studies seem to emerge almost weekly. A 2007 analysis of vitamin D studies found that individuals with higher vitamin D levels are significantly – as much as 50 per cent – less likely to develop colorectal cancer. Another 2007 study found that women who took 1,100 International Units (IU) of vitamin D per day together with a calcium supplement reduced their overall cancer risk by 60 per cent. And the excitement is not only about cancer prevention.
Low vitamin D levels have been linked to an increased risk of osteoporosis, heart disease, multiple sclerosis, type 1 diabetes, depression and rheumatoid arthritis, among other diseases. Perhaps not surprisingly, in light of the other studies, one recent review of the health records of more than 13,000 Americans found that individuals with the lowest vitamin D levels were 26 per cent more likely, in an eight-year period, to die than those with the highest levels. ... the best research suggests that to achieve the higher vitamin D blood levels associated with disease prevention, most adults in the US would need to take 1,000-2,000 IU a day: five to 10 times more than the current official recommendation for adults. ...
June 28, 2010Vitamin D Council website being improved now http://www.vitaminDcouncil.org
Below is an excellent article on why governments are not acting on vitamin D and are not likely to act anytime soon:
http://www.ft.com/cms/s/2/11180df8-beaa-11de-b4ab-00144feab49a.html
John Cannell (He hired an expert make his website much more user friendly. It is still in progress. Jim)
Vitamin D Council1241 Johnson Ave.., #134
San Luis Obispo, CA 93401
Saturday, May 22, 2010
Vitamin D: Why You Are Probably NOT Getting Enough and How That Makes You Sick
What vitamin may we need in amounts up to 25 times higher than the government recommends for us to be healthy?
What vitamin deficiency affects 70-80 percent of the population, is almost never diagnosed and has been linked to many cancers, high blood pressure, heart disease, diabetes, depression,(i) fibromyalgia, chronic muscle pain, bone loss and autoimmune diseases like multiple sclerosis?(ii) ...
Overall, 7.6 million, or nine percent, of US children were vitamin-D deficient, and another 50.8 million, or 61 percent, had insufficient levels of this important vitamin in their blood.
The average blood level of vitamin D was 25 ng/dl for Caucasians and 16 ng/dl for African Americans. The optimal level is 45 ng/dl and requires about 3000-4000 IU a day of vitamin D3 -- 10 times current recommendations. If our whole population achieved a minimum level of 45 ng/dl, we would have 400,000 fewer premature deaths per year. There would be a reduction of cancer by 35 percent, type 2 diabetes by 33 percent and all causes of mortality by seven percent. (iv)
The economic burden due to vitamin D insufficiency in the United States is $40-$53 billion per year. This can be corrected for pennies a person per day. ...
How Vitamin D Regulates Your Cells and Genes
Vitamin D has a dramatic impact on the health and function of your cells. It reduces cellular growth (which promotes cancer) and improves cell differentiation (which puts cells into an anti-cancer state). That makes vitamin D one of the most potent cancer inhibitors--and explains why vitamin D deficiency has been linked to colon, prostate, breast and ovarian cancer.
But what's even more fascinating is how vitamin D regulates and controls genes.
It acts on a cellular docking station called a receptor that then sends messages to our genes. That's how vitamin D controls so many different functions--like preventing cancer, reducing inflammation, boosting mood, easing muscle aches and fibromyalgia and building bones.
Vitamin D also helps prevent the flu and colds and infections. In an observational study of Finnish soldiers, those with 25-hydroxyvitamin D levels higher than 16 ng/mL (40 nmol/L) had fewer respiratory infections than those with lower levels.(v) More recently, in a double-blind randomized controlled trial involving school girls, supplementation with 1200 IU/d of vitamin D3 during the wintertime significantly reduced influenza A infections.(vi) ...
Your body makes vitamin D when it's exposed to sunlight. In fact, 80 to 100 percent of the vitamin D we need comes from the sun. The sun exposure that makes our skin a bit red (called 1 minimum erythemal dose) produces the equivalent of 10,000 to 25,000 international units (IU) of vitamin D in our bodies.
The problem is that most of us aren't exposed to enough sunlight.
Overuse of sunscreen is one reason. While these product help protect against skin cancer--they also block a whopping 97 percent of your body's vitamin D production.
If you live in a northern climate, you're not getting enough sun (and therefore vitamin D), especially during winter. And you're probably not eating enough of the few natural dietary sources of vitamin D: fatty wild fish like mackerel, herring and cod liver oil or porcini mushrooms.
In addition, aging skin produces less vitamin D--the average 70-year-old person creates only 25 percent of the vitamin D that a 20 year-old does. Skin color makes a difference, too. People with dark skin also produce less vitamin D. And I've seen very severe deficiencies in Orthodox Jews and Muslims who keep themselves covered all the time.
With all these causes of vitamin D deficiency, you can see why supplementing with enough of this vitamin is so important. Unfortunately, you aren't really being told the right amount of vitamin D to take.
The government recommends 200 to 600 IU of vitamin a day. This is the amount you need to prevent rickets, a disease caused by vitamin D deficiency. But the real question is: How much vitamin D do we need for OPTIMAL health? How much do we need to prevent autoimmune diseases, high blood pressure, fibromyalgia, chronic muscle pain,(vii) depression, osteoporosis and even cancer?
The answer is: Much more than you think.
Recent research by vitamin D pioneer Dr. Michael Holick, Professor of Medicine, Physiology, and Dermatology at Boston University School of Medicine, recommends intakes of up to 2,000 IU a day -- or enough to keep blood levels of 25 hydroxy vitamin D at between 75 to 125 nmol/L (nanomoles per liter).(viii) That may sound high, but it's still safe: Lifeguards have levels of 250 nmol/L without toxicity.
Our government currently recommends 2,000 IU as the upper limit for vitamin D -- but even that may not be high enough for our sun-deprived population! In countries where sun exposure provides the equivalent of 10,000 IU a day and people have vitamin D blood levels of 105 to 163 nmol/L, autoimmune diseases(like multiple sclerosis, type 1 diabetes, inflammatory bowel disease, rheumatoid arthritis and lupus) are uncommon. (Divide nmol/L by 2.5 to get ng/ml, the units used in USA. Jim)
Don't be scared that amounts that high are toxic: One study of healthy young men receiving 10,000 IU of vitamin D for 20 weeks showed no toxicity.(ix)
You might have seen a recent study in the Journal of the American Medical Association that shows that a single high dose of 500,000 Units of vitamin D3 (one year's worth of vitamin D) increased the risk of falls and fractures in elderly woman.(x) Does this mean that vitamin D doesn't prevent fractures or falls? Absolutely not! (Yes, many smart scientists can be very very stupid as I found when I worked among Ivy League Harvard and MIT scientists and engineers. Jim)
The design and logic of the study were completely wrong. As a friend once said, "The well meaning are often ill doing."
Imagine a study that gave people a year's worth of vitamin A, or iron (both are nutrients that are stored in the body like vitamin D) in one dose. The vitamin A would cause immediate liver failure and death. In fact, the way the Inuit used to kill explorers in the Arctic was to feed them polar bear liver, which gave them toxic doses of vitamin A. A year's worth of iron in one dose would cause severe intestinal problems and iron poisoning.
Biologically we understand why a single high dose of vitamin D may cause problems. A single high dose induces protective mechanisms that reduce the available vitamin D by increasing the activity of enzymes that cause the vitamin D to be broken down by the body. (xi) The body requires a balance of the right nutrients at the right dose at the right time. No one would eat a year's worth of anything in one day and expect it to be healthy. ...
6 Tips for Getting the Right Amount of Vitamin D
Unless you're spending all your time at the beach, eating 30 ounces of wild salmon a day, or downing 10 tablespoons of cod liver oil a day, supplementing with vitamin D is essential. The exact amount needed to get your blood levels to the optimal range (100 to160 nmol/L) will vary depending on your age, how far north you live, how much time you spend in the sun and even the time of the year. But once you reach optimal levels, you'll be amazed at the results.
For example, one study found that vitamin D supplementation could reduce the risk of getting type 1 diabetes by 80 percent.(xii) In the Nurses' Health Study (a study of more than 130,000 nurses over 3 decades), vitamin D supplementation reduced the risk of multiple sclerosis by 40 percent.(xiii),(xiv)
I've seen many patients with chronic muscle aches and pains and fibromyalgia who are vitamin D deficient--a phenomenon that's been documented in studies. Their symptoms improve when they are treated with vitamin D. A Danish study of Arabic women with fibromyalgia found significant vitamin D deficiency and recovery with replacement of vitamin D.(xv)
Finally, vitamin D has been shown to help prevent and treat osteoporosis. In fact, it's even more important than calcium. That's because your body needs vitamin D to be able to properly absorb calcium. Without adequate levels of vitamin D, the intestine absorbs only 10 to 15 percent of dietary calcium. Research shows that the bone-protective benefits of vitamin D keep increasing with the dose.
So here is my advice for getting optimal levels of vitamin D:
1. Get tested for 25 OH vitamin D. The current ranges for "normal" are 25 to 137 nmol/L or 10 to 55 ng/ml. These are fine if you want to prevent rickets -- but NOT for optimal health. In that case, the range should be 100 to 160 nmol/L or 40 to 65 ng/ml. In the future, we may raise this "optimal" level even higher. ... Five more important tips and medical references http://www.huffingtonpost.com/dr-mark-hyman/vitamin-d-why-you-are-pro_b_585311.html
Tuesday, May 18, 2010
Eating Processed Meat, such as bacon, sausage or processed deli meats: 42% Higher Risk Heart Disease
The study appears online May 17, 2010, on the website of the journalCirculation."Although most dietary guidelines recommend reducing meat consumption, prior individual studies have shown mixed results for relationships between meat consumption and cardiovascular diseases and diabetes," said Renata Micha, a research fellow in the department of epidemiology at HSPH and lead author of the study. "Most prior studies also did not separately consider the health effects of eating unprocessed red versus processed meats." ...