Showing posts with label diabetes. Show all posts
Showing posts with label diabetes. Show all posts

Saturday, April 9, 2011

Alzheimer’s Diabetes Brain New Theory Insulin Lack Toxic to Brain as are Nitrosamine Meats and Very Low LDL

Tags: Alzheimer's Cause Brain Toxins New Theory Diabetes of Brain Low Insulin, Nitrosamine Meats, Very Low Density Lipoproteins, Diabetes, Obesity, Fructose triglycerides into very low LDL, Uric Acid

Alzheimer’s Diabetes Brain New Theory Insulin Lack Toxic to Brain as are Nitrosamine Meats and Very Low LDL

Our brain uses more sugar than any other part of our body. Diabetes of the brain is especially damaging to the neurons.

Bottom Line: Fructose metabolizes in the liver to triglycerides which further metabolizes to Very Low Density Lipoproteins which are toxic to the brain, one cause of Alzheimer's Disease. High source High Fructose Corn Syrup in processed soft drinks, (Sunkist soda equals 6 Breyer Oreo Ice Creams) processed foods, and Fast Foods Including most drinks including Starbucks Mocha (660 calories 95 grams sugar) and McDonalds coffee drinks and shakes enormous amounts of this sugar.

Diabetes off the Brain when insulin resistance results from High Fructose Corn Syrup and sucrose sugar. The difference is that the syrup can be place in much higher amounts in food and drinks without crystallizing out, and High Fructose makes foods more palatable.

Diabetes and Obesity mushroomed when Reagan in the mid-1980s, without FDA testing, subsidized corn to very high levels to make High Fructose Corn Syrup very cheap to help the processed food corporations greatly improve their profits and replaced sucrose as the sweetener of choice. Placement in soft drinks is probably the major cause of the diabetes, Obesity, and Alzheimer's crisis. Americans consume about 150 lbs yearly of this metabolic poison.

Nitrates used in preserving hot dogs, deli meats and some cheeses, turn into deadly nitrosamine which is toxic to our brain.

Very low density lipoproteins are toxic to our brain. Produced from triglycerides in the liver.

Fructose metabolism also produces uric acid from our cells after destroying them by destroying the mitochondria. Uric acid causes inflammation of the blood vessels leading to higher blood pressure and possibly inflamed brain protective membrane. Recent data shows that uric acid range is too high and uric acid levels (test) should be below 4.5 for males and lower for females. Most uric acid comes from the cell metabolism of fructose. Colas and juices, especially apple and grape juice have high amounts of fructose. Almost all processed foods still contain high levels of High Fructose Corn Syrup.
Fructose metabolism in the liver does lead to cirrhosis in a similar manner as sucrose and alcohol metabolism.

Using Round Up weed killer over our genetically modified crops results in residual toxic chemicals left on the food crop. Whether they cause any of our common diseases or bad health is unknown. Corporate producers do not allow academics, unless under contract, to study whether these foods are safe. Clinton and Bush approved their use after being convinced by Monsanto and other lobbyists and placing their top lobbyist in one step to the top in our FDA probably helped with the approval process without testing!

The theme of the Dr. Oz Show, ABC 3:00 PM, daily, was that what we eat can cause Alzheimer’s Disease. Dr. Suzanne DeLaMonte, a neuropathologist at the Rhode Island Hospital, appeared on the Dr. Oz show www.doctoroz.com to explain her new findings on the cause of Alzheimer’s Disease. Before appearing on the show, Dr. Oz discussed it with many brain Scientists at Columbia who have been on the gene kick forever, including a Nobel Prize winner, and they apparently found Dr. DeLaMonte’s work well done.

I expressed my skepticism about so much emphasis on genes causing Alzheimer’s for many years. I explained that both genetic (Body can’t degrade very low density lipoproteins easily) and late onset Alzheimer’s are caused by a similar mechanism. Very low density lipoproteins. The LDL we get from routine blood tests includes it, but does not tell us how much of the deadly very low density lipoproteins are there.

Alzheimer’s and Obesity starting in the mid-1980s when Reagan arbitrarily approved synthetic High Fructose Corn Syrup using an enzymatic process starting from corn sugar developed by Japanese scientists in 1971. However corn was too expensive to make this sugar commercial. Reagan changed that by subsidizing corn in the mid-1980s so greatly that farmers make most of their minor income from just the corn subsidy which taxpayers provide which forces farmers to maximize their production of corn or starve.

The corn to ethanol program was also a partial subsidy for the farmers and high profits for the producers of ethanol. The higher demand increases the price of corn and its production so other food crops are now scarce causing a sharp rise in prices. Corn prices have doubled in the last several years. If we include all use of oil for its production, we really do not lessen the use of oil.

Why High-Fructose Syrup Causes Insulin Resistance: Dr. Mercola’s Comments: According to the latest statistics, new cases of diabetes have increased by 90 percent in the last 10 years, and diabetes or pre-diabetes now strikes one in four Americans. Those are absolutely astounding statistics to say the least.

There’s no doubt in my mind that one of the primary fuels for this epidemic is the excess consumption of high fructose corn syrup (HFCS). Several studies over the past few years have also come to this conclusion, including this latest study in Cell Metabolism, in which the researchers note:

“Insulin resistance is a common feature of the metabolic syndrome and type 2 diabetes mellitus (T2DM). Both have reached epidemic proportions worldwide with the global adoption of the westernized diet along with increased consumption of fructose, stemming from the wide and increasing use of high-fructose corn syrup sweeteners.

It is well established that fructose is more lipogenic than glucose, and high-fructose diets have been linked to hypertriglyceridemia, nonalcoholic fatty liver disease (NAFLD), and insulin resistance.” ...

Recently, I briefly discussed the narrowness of thinking about gene being relevant in most Alzheimer's cases about a recent article by Kolata of the NY Times http://www.nytimes.com/2011/04/04/health/04alzheimer.html?_r=1&scp=1&sq=Alzheimers%20Gene&st=cse about a large study showing that about ten genes were correlated (note correlated) with Alzheimer’s in a worldwide combining of DNA structure gene data. Sharon Begley, well ahead of we common folks in seeing the forest instead of the trees. Now with Newsweek, now a great news magazine, commented Alzheimer's: Still Barking Up the Wrong Tree? http://www.sharonlbegley.com/alzheimer-s-still-barking-up-the-wrong-tree while at the Wall Street Journal.

Other related articles by Begley: http://www.newsweek.com/2011/02/27/i-can-t-think.html http://www.newsweek.com/2010/08/05/the-limits-of-reason.html that researchers think and do research in such a narrow field that they are unable think beyond that. …

Wikipedia Fructose: … Fructose Metabolism By The Brain Increases Food Intake And Obesity, Review Suggests (Mar. 26, 2009) — Scientists have built on the suggested link between the consumption of fructose and increased food intake, which may contribute to a high incidence of obesity and type 2 ... > read more ... See PDF.

Jim Kawakami, April 9, 2011, http://jimboguy.blogspot.com

Saturday, May 22, 2010

Vitamin D: Why You Are Probably NOT Getting Enough and How That Makes You Sick

Tags: Low Vitamin D, Linked to many cancers, colon, prostate, breast and ovarian cancer, high blood pressure, heart disease, diabetes, depression,(i) fibromyalgia, chronic muscle pain, bone loss and autoimmune diseases like multiple sclerosis, lupus, religion, Optimal levels D, reducing inflammation, boosting mood, colds, flu, muscles pain, osteoporosis, Multiple Sclerosis, type 1 diabetes, inflammatory bowel disease, depends on skin color, genetics of vitamin D efficiency (not same for Whites and Blacks),

Finally an article with both credibility and clarity! One of the few articles where I had to make comments to try to clarify what is extremely important about taking vitamin D. Best article yet! I recommend you go to the Huff Post link below to get the full story.

Jim Kawakami, May 22, 2010, http://jimboguy.blogspot.com

What vitamin may we need in amounts up to 25 times higher than the government recommends for us to be healthy?

What vitamin deficiency affects 70-80 percent of the population, is almost never diagnosed and has been linked to many cancers, high blood pressure, heart disease, diabetes, depression,(i) fibromyalgia, chronic muscle pain, bone loss and autoimmune diseases like multiple sclerosis?(ii) ...

Overall, 7.6 million, or nine percent, of US children were vitamin-D deficient, and another 50.8 million, or 61 percent, had insufficient levels of this important vitamin in their blood.

The average blood level of vitamin D was 25 ng/dl for Caucasians and 16 ng/dl for African Americans. The optimal level is 45 ng/dl and requires about 3000-4000 IU a day of vitamin D3 -- 10 times current recommendations. If our whole population achieved a minimum level of 45 ng/dl, we would have 400,000 fewer premature deaths per year. There would be a reduction of cancer by 35 percent, type 2 diabetes by 33 percent and all causes of mortality by seven percent. (iv)

The economic burden due to vitamin D insufficiency in the United States is $40-$53 billion per year. This can be corrected for pennies a person per day. ...

How Vitamin D Regulates Your Cells and Genes

Vitamin D has a dramatic impact on the health and function of your cells. It reduces cellular growth (which promotes cancer) and improves cell differentiation (which puts cells into an anti-cancer state). That makes vitamin D one of the most potent cancer inhibitors--and explains why vitamin D deficiency has been linked to colon, prostate, breast and ovarian cancer.

But what's even more fascinating is how vitamin D regulates and controls genes.

It acts on a cellular docking station called a receptor that then sends messages to our genes. That's how vitamin D controls so many different functions--like preventing cancer, reducing inflammation, boosting mood, easing muscle aches and fibromyalgia and building bones.

Vitamin D also helps prevent the flu and colds and infections. In an observational study of Finnish soldiers, those with 25-hydroxyvitamin D levels higher than 16 ng/mL (40 nmol/L) had fewer respiratory infections than those with lower levels.(v) More recently, in a double-blind randomized controlled trial involving school girls, supplementation with 1200 IU/d of vitamin D3 during the wintertime significantly reduced influenza A infections.(vi) ...

Your body makes vitamin D when it's exposed to sunlight. In fact, 80 to 100 percent of the vitamin D we need comes from the sun. The sun exposure that makes our skin a bit red (called 1 minimum erythemal dose) produces the equivalent of 10,000 to 25,000 international units (IU) of vitamin D in our bodies.

The problem is that most of us aren't exposed to enough sunlight.

Overuse of sunscreen is one reason. While these product help protect against skin cancer--they also block a whopping 97 percent of your body's vitamin D production.

If you live in a northern climate, you're not getting enough sun (and therefore vitamin D), especially during winter. And you're probably not eating enough of the few natural dietary sources of vitamin D: fatty wild fish like mackerel, herring and cod liver oil or porcini mushrooms.

In addition, aging skin produces less vitamin D--the average 70-year-old person creates only 25 percent of the vitamin D that a 20 year-old does. Skin color makes a difference, too. People with dark skin also produce less vitamin D. And I've seen very severe deficiencies in Orthodox Jews and Muslims who keep themselves covered all the time.

With all these causes of vitamin D deficiency, you can see why supplementing with enough of this vitamin is so important. Unfortunately, you aren't really being told the right amount of vitamin D to take.

The government recommends 200 to 600 IU of vitamin a day. This is the amount you need to prevent rickets, a disease caused by vitamin D deficiency. But the real question is: How much vitamin D do we need for OPTIMAL health? How much do we need to prevent autoimmune diseases, high blood pressure, fibromyalgia, chronic muscle pain,(vii) depression, osteoporosis and even cancer?

The answer is: Much more than you think.

Recent research by vitamin D pioneer Dr. Michael Holick, Professor of Medicine, Physiology, and Dermatology at Boston University School of Medicine, recommends intakes of up to 2,000 IU a day -- or enough to keep blood levels of 25 hydroxy vitamin D at between 75 to 125 nmol/L (nanomoles per liter).(viii) That may sound high, but it's still safe: Lifeguards have levels of 250 nmol/L without toxicity.

Our government currently recommends 2,000 IU as the upper limit for vitamin D -- but even that may not be high enough for our sun-deprived population! In countries where sun exposure provides the equivalent of 10,000 IU a day and people have vitamin D blood levels of 105 to 163 nmol/L, autoimmune diseases(like multiple sclerosis, type 1 diabetes, inflammatory bowel disease, rheumatoid arthritis and lupus) are uncommon. (Divide nmol/L by 2.5 to get ng/ml, the units used in USA. Jim)

Don't be scared that amounts that high are toxic: One study of healthy young men receiving 10,000 IU of vitamin D for 20 weeks showed no toxicity.(ix)

You might have seen a recent study in the Journal of the American Medical Association that shows that a single high dose of 500,000 Units of vitamin D3 (one year's worth of vitamin D) increased the risk of falls and fractures in elderly woman.(x) Does this mean that vitamin D doesn't prevent fractures or falls? Absolutely not! (Yes, many smart scientists can be very very stupid as I found when I worked among Ivy League Harvard and MIT scientists and engineers. Jim)

The design and logic of the study were completely wrong. As a friend once said, "The well meaning are often ill doing."

Imagine a study that gave people a year's worth of vitamin A, or iron (both are nutrients that are stored in the body like vitamin D) in one dose. The vitamin A would cause immediate liver failure and death. In fact, the way the Inuit used to kill explorers in the Arctic was to feed them polar bear liver, which gave them toxic doses of vitamin A. A year's worth of iron in one dose would cause severe intestinal problems and iron poisoning.

Biologically we understand why a single high dose of vitamin D may cause problems. A single high dose induces protective mechanisms that reduce the available vitamin D by increasing the activity of enzymes that cause the vitamin D to be broken down by the body. (xi) The body requires a balance of the right nutrients at the right dose at the right time. No one would eat a year's worth of anything in one day and expect it to be healthy. ...

6 Tips for Getting the Right Amount of Vitamin D

Unless you're spending all your time at the beach, eating 30 ounces of wild salmon a day, or downing 10 tablespoons of cod liver oil a day, supplementing with vitamin D is essential. The exact amount needed to get your blood levels to the optimal range (100 to160 nmol/L) will vary depending on your age, how far north you live, how much time you spend in the sun and even the time of the year. But once you reach optimal levels, you'll be amazed at the results.

For example, one study found that vitamin D supplementation could reduce the risk of getting type 1 diabetes by 80 percent.(xii) In the Nurses' Health Study (a study of more than 130,000 nurses over 3 decades), vitamin D supplementation reduced the risk of multiple sclerosis by 40 percent.(xiii),(xiv)

I've seen many patients with chronic muscle aches and pains and fibromyalgia who are vitamin D deficient--a phenomenon that's been documented in studies. Their symptoms improve when they are treated with vitamin D. A Danish study of Arabic women with fibromyalgia found significant vitamin D deficiency and recovery with replacement of vitamin D.(xv)

Finally, vitamin D has been shown to help prevent and treat osteoporosis. In fact, it's even more important than calcium. That's because your body needs vitamin D to be able to properly absorb calcium. Without adequate levels of vitamin D, the intestine absorbs only 10 to 15 percent of dietary calcium. Research shows that the bone-protective benefits of vitamin D keep increasing with the dose.

So here is my advice for getting optimal levels of vitamin D:

1. Get tested for 25 OH vitamin D. The current ranges for "normal" are 25 to 137 nmol/L or 10 to 55 ng/ml. These are fine if you want to prevent rickets -- but NOT for optimal health. In that case, the range should be 100 to 160 nmol/L or 40 to 65 ng/ml. In the future, we may raise this "optimal" level even higher. ... Five more important tips and medical references http://www.huffingtonpost.com/dr-mark-hyman/vitamin-d-why-you-are-pro_b_585311.html

Friday, May 14, 2010

Vit. D: Pregnancy, Breast, Libido, Autism, Schizophrenia, Depression, Heart, Stroke, Diabetes, High BP, Acne

Tags: Vit. D: Pregnancy, Breast, Libido, Autism, Schizophrenia, Depression, Heart, Stroke, Diabetes, High BP, Acne

Oil is in the news now, but very little about the real health benefits of Americans using less sunscreen and greatly increasing the vitamin D3 daily to at least 2,000 IU and up to 5,000 IU.

As I mentioned in the past, vitamin D really boosted my testosterone level from normal for someone my age to levels seen in teenagers. Yes, it has really increased my Libido as some rumors in the news has mentioned.

The establishment is always conservative to preserve their place in the hierarchy.

I was cursed or blessed with a level of independence not accepted in our current society so I am generally skeptical of those who have the gift (inherited) of gab and are part of the Establishment.

We have seen in our political debates that confirmed facts have no place in what they say. Republicans and the media are now blaming Obama for screwing up on the oil spill now. First let me remind you that several years ago the NY Times has an obscured article that mentioned that Obama was really worried about Bush putting in ideological troops into our civil service system whose employees are hard to remove. That is why the Republicans refused to approve a competent and honest leader for the Oils and Mineral unit which has strong control of off-shore drilling requirements. Apparently these Bush Boys violated all protocol and ignored the role of other agencies regulating off-shore oil rigs. The Swiss company flew the flag of the Marshal Islands as reported by Rachel Maddow http://www.msnbc.msn.com/id/26315908/ns/msnbc_tv-rachel_maddow_show/#37141886

The blind adherence by doctors, scientists, and others to the role of sunscreen UVB use causing all sorts of illnesses including osteoporosis without realizing that vitamin D is critical not only for bones but for our overall health including our immune system.

Here are some of the letters to Dr. John Cannell of www.vitaminDcouncil.com from all over the world seeking council on vitamin D by medical doctors and others whose children have serious health problems including acne for teenagers.

Suzy, give Mike this because his website does not accommodate more than one page long e-mails. Thanks!

Jim Kawakami, May 14, 2010, http://jimboguy.blogspot.com

Vitamin D Council www.vitaminDcouncil.org

John Cannell, MD
Executive Director
Vitamin D Council
You may reproduce this newsletter as long as you properly and prominently attribute it source. Please reproduce it, post it on Internet sites, and forward it to your friends. Remember, we are a non-profit and rely on your donations to publish our newsletter, maintain our website, and pursue our objectives. Send your tax-deductible contributions to: The Vitamin D Council
Dear Dr. Cannell:
I have a four-month-old infant and I am worried because I only took a prenatal vitamin during my pregnancy but no extra vitamin D. I am breastfeeding but I give him formula as well as breast milk. Do I need to give him extra vitamin D?
Jeanne, England
Dear Jeanne:
Yes, you do. In fact, CDC researchers just announced that less than 25% of U.S. infants are getting the outdated recommended amount of vitamin D (400 IU/day). I suspect the situation is worse in England. Dr. Cria Perrine and her colleagues at the CDC analyzed questionnaires sent to over 15,000 mothers with infants ranging in age from 1-10 months.
The breast milk of vitamin D deficient mothers contains little vitamin D and virtually all mothers are deficient, thus breast milk usually has little vitamin D. Dr. Perrine found that only about 10% of breast-feeding infants are supplemented to meet the 400 IU/day recommendation; more surprising, only about 30% of formula-fed infants were getting 300 IU/day, mainly because few infants consume the one liter of formula needed to do so.
One bad sign, Dr. Perrine reiterated the 1999 American Academy of Pediatrics sunshine warning, which amounts to child abuse, stating, “children under the age of 6 months should be kept out of the sun altogether and that those aged 6 months or older should wear protective clothing and sunscreen to minimize sun exposure.” One good sign, WebMD mentioned that adequate amounts of vitamin D might prevent respiratory infections in infants.
The vitamin D Council recommends that breastfeeding infants under one year of age take 1,000 IU/day unless the mother takes 5,000 IU/day, in which case the infants will get all they need from breast milk. Formula fed infants need an extra 600 IU/day. Carlson Ddrops, either 400, 1,000 or 2,000 IU/drop are available at most health food stores and on the internet; they are an easy way to keep your infant vitamin D sufficient. I understand that similar dropper products are available in England’s health food stores. By the way, Dr. Carol Wagner and Bruce Hollis have just presented their data about pregnant women and vitamin D.
Boyles S. High Doses of Vitamin D May Cut Pregnancy Risks: Study Shows 4,000 IU a Day of Vitamin D May Reduce Preterm Birth and Other Risks. WebMd, May 4, 2010. Their study had two treatment arms; pregnant women took either 2,000 IU/day and 4,000 IU/day. In Belgium, Dr. Hollis reported their findings forced them to discontinue the 2,000 IU/day treatment arm for ethical reasons: it was associated with more obstetrical complications than the 4,000 IU/day treatment arm.
John Cannell
Dear Dr. Cannell:
Is there anything out there about vitamin D and libido? I am asking because I have noticed an increase in my libido (I am a 48-year-old male who has been getting 5,000 IU/day shipped to me in France from Bio Tech Pharmacal for about a year.)
Philippe, France
Dear Philippe:
I know of no studies measuring male libido and vitamin D but Dr. Wehr and colleagues, at the Medical University of Graz in Austria, just published a surprising study showing that testosterone levels are directly associated with vitamin D levels (measured with the DiaSorin technique) and testosterone levels vary with the seasons, in concert with vitamin D levels. Furthermore, the men with very low testosterone levels had very low vitamin D levels. This study does not prove, like any association study, that vitamin D increases testosterone levels. It may be that sun-exposure in the summer is responsible for both higher vitamin D levels and higher testosterone levels.
By the way, the New York Daily News got it wrong, nothing in the Wehr study talks about vitamin D increasing male libido.
John Cannell
Dear Dr. Cannell:
I work with the Somali immigrant community in Ottawa. If you see how healthy these immigrants are when they come here and how terrible their health is after a few years it is hard to see how it could be anything but vitamin D. Why do the health officials in Canada do nothing?
Gail, Ottawa
Dear Gail:
What is going on in Ottawa is a crime against people of color, just as what is going on against African Americans in the USA is a crime. It is not just autism, but schizophrenia, depression, heart attack, stroke, diabetes, and hypertension, are all diseases associated with vitamin D deficiency and also associated with dark skin in temperate latitudes.
African Americans die almost eight years younger than Whites do, due to the diseases of vitamin D deficiency. I hoped the Obama administration might do something, but so far nothing. Perhaps we should file our civil rights complaint again, like the one we filed in 2005, which then Attorney General Alberto Gonzales summarily dismissed:
Dear Eric:
Isotretinoin or 13-cis-Retinoic Acid (Accutane in the USA) is a retinoid used in severe acne and rosacea as well as in cancer chemotherapy. It may have the same effects on the vitamin D receptor as other retinols. It certainly interferes with vitamin D metabolism.
For those taking Isotretinoin for cancer, continue doing what your oncologist says to do, but also get your 25(OH)D to at least 100 ng/ml. If you are taking Isotretinoin for acne, my advice is to stop the Isotretinoin and take adequate doses of vitamin D.
In 1938, Dr. Merlin Maynard showed vitamin D helped acne more than one of the most effective treatments of all time, x-ray treatment. You can download his entire paper for free.
Dr. Maynard wrote beautifully:
There is probably no skin disease of greater importance to the human race than acne. It is undoubtedly our commonest skin disease, and it is rare that any individual reaches maturity without having had it in one of its phases. It is a disease of considerable economic importance, as the disfiguring scars of a severe case are never completely obliterated. It is also a disease of youth. It attains its most noxious form at the time the individual first has to earn his own living. It is undoubtedly responsible for many failures in getting business positions. It is also the basis for inferiority complexes and discouragement in young people.
Dr. Maynard published a long case series. In his earlier days, he used x-ray treatment for acne, but when he started using viosterol (vitamin D2) he stopped using x-ray treatment. In reviewing his cases, he found x-ray treatment led to favorable results 48% of the time but vitamin D did so 76% of the time; he used between 5,000 and 14,000 IU per day. Vitamin D3 may work even better than D2, if acne patients take adequate doses, like 10,000 IU/day with frequent 25(OH)D levels.
In summary, he said:
I believe I may say that at no time in my dermatological experience have I felt such complete satisfaction with a treatment as I have with the cases of this series. I know that vitamin D is an imperfect weapon to slay this disfiguring disease, but it undoubtedly gives one a feeling of being well defended. From the patients' viewpoint, it has left little to be desired, as they find themselves improving, both in appearance and in general well-being. Many have expressed the sentiment, ‘Never felt better.’
In 2008, the mechanism of action of vitamin D in the skin was the subject of a lengthy review:
Theoretically, rosacea should not respond to vitamin D, just the opposite, but readers have told me it does. However, if you have been on Isotretinoin, it may take months or years for the excessive vitamin A to get out of your system. The excess vitamin A may continue to compete for the vitamin D’s receptors attention and, until the vitamin A is gone, one may not see the full effects of vitamin D. By the way, just ask any acne patient if their acne gets better after a week of sunning at the beach.
John Cannell
Dear Dr. Cannell:
I am a naturopath in Montréal, Canada. I work primarily in mental health. I did a search on MDConsult recently for "Differential diagnosis of psychosis." One of the differential diagnoses in the list was vitamin D deficiency. I am unable to find any research that supports that, and that list had no citations. Do you know anything about it?
I have a patient who recently experienced some of the most extreme psychosis of his life. During that time, I measured his Vitamin D. It was too low to be detected! I started him on 5,000 IU per day and had measured it a few months later, when he was doing much better, and it was 22 ng/ml. I thought there was a relationship between the deficiency and the psychosis, but could not find anything on PubMed or anywhere else about the connection.
Any thoughts on that?
Melissa, Canada
Dear Melissa:
This is good news; however, I am not aware of any papers on the treatment of psychosis with vitamin D. At my hospital, which now has a policy to test all new patients for vitamin D deficiency, several of us have noticed that a few psychotic patients seem to get remarkably better on vitamin D, and others can reduce the dose of their meds, once their vitamin D deficiency is treated. However, the vast majority of patients must stay on meds or they relapse. However, no one, to my knowledge, has treated psychotic patients with pharmaceutical doses, like 20,000 IU per day. It would not surprise me at all if researchers found that dose to be effective treatment in some cases of psychosis.
The scientific community has never researched the issue of using vitamin D as a drug, that is, as a pharmaceutical. If one was free to use pharmaceutical doses, as psychiatrists in private practice are free to do, they could rapidly lend some light to the subject by treating psychotic patients with both antipsychotic meds and with 20,000 IU per day and carefully follow 25(OH)D, calcium, and clinical course. I suspect they would find a vitamin D treatment effect. If they did such a case series, I would publish their reports in this newsletter, be they negative or positive.
John Cannell
Dear Seth:
Yes, divide nmol/L by 2.5 to get ng/ml. In the USA, all labs report 25(OH)D levels as ng/ml so no division is needed. As far as our website goes, the conversion is now on it, thank you. The English company Minervation is well into a two-year project of greatly improving our website. Dr. William Grant, a member of our Board, is working closely with Minervation to get the science right. The current website began in 2003 when I spent several months writing it and my son then published it on the internet, so it is far from perfect.
John Cannell