Wednesday, October 27, 2010

Glucosamine Excess Causes Death of Pancreatic Cells Increase Diabetes Fructose

Tags: Glucosamine Death of Pancreatic Cells High Fructose Corn Sugar Overweight High BP Uric Acid

Seniors who use glucosamine for knee pain may need to consult your doctors showing this article to determine whether you should continue its use.

Americans tend to be in an overdose culture where if little is good for you, using much more means it is even better. For example using large amounts of calcium supplements without about half of it being magnesium will tend to diminish the amount of magnesium in our body.

Our optimum healthy body is a balance of many chemicals, hormones, vitamins, and other nutrients, especially water in abundance. Tea colored urine means you are not drinking enough water. Don’t forget that any sweetener activates our hunger pangs. For example eating your desert first may help you enjoy your meal better.

Sugar from corn tends to makes us eventually hungry all the time. Cane or Beet sugar does not do that. Don’t believe the so-called experts who say both sugars are the same metabolically because High Fructose Corn Syrup goes more directly to our liver which produces 30 percent deadly very low density lipoproteins cholesterol.

They are not. Going on a complete a fructose fast for two weeks to clear out the high concentration of fructose enzymes will stop you from craving this sugar. It makes you fat because you eat a lot more. Limit yourself to no more than one or two fruits a day and some vitamin C tablet, maybe 250-500 mg.

Uric acid raises your blood pressure by generating nitric acid and inflames your blood vessels. It results from the metabolism of fructose by the consumption of your energy source ATP in cells which produces purine which goes on to uric acid. It may also prevent White blood cells from entering your brain and possibly precursors to form the enzyme needed to get rid of excess proteins which I think causes dementia and Alzheimer’s Disease by blocking the synaptic connections in the brain.

High purine foods such as sardines or other dark meat fish and all shell fish have high amounts of purine and should be eaten only once a month. Tuna only once a week.

Levels below 5.5 mg/dl uric acid are recommended. Each increase of 1 mg/dl uric acid increases weight by 10 pounds, increases cholesterol by 46 mg/dl, and a 10 mm rise in blood pressure. With this low fructose diet, I am never hungry and I have easily lost ten pounds. I could lose more by not eating hard cheese, but I still do. Drinking milk seems to lower fructose in the blood. Not sure why. Read The Sugar Fix: The High-Fructose Fallout that is Making You Fat and Sick by Richard J. Johnson, MD with Timothy Gower. Easy to read and well organized.

Jim Kawakami, Oct 27, 2010,

Glucosamine Excess Causes Death of Pancreatic Cells Increase Diabetes

ScienceDaily (Oct. 27, 2010) — High doses or prolonged use of glucosamine causes the death of pancreatic cells and could increase the risk of developing diabetes, according to a team of researchers at Université Laval's Faculty of Pharmacy. Details of this discovery were recently published on the website of the Journal of Endocrinology.

In vitro tests conducted by Professor Frédéric Picard and his team revealed that glucosamine exposure causes a significant increase in mortality in insulin-producing pancreatic cells, a phenomenon tied to the development of diabetes. Cell death rate increases with glucosamine dose and exposure time. "In our experiments, we used doses five to ten times higher than that recommended by most manufacturers, or 1,500 mg/day," stressed Professor Picard. "Previous studies showed that a significant proportion of glucosamine users up the dose hoping to increase the effects," he explained.

Picard and his team have shown that glucosamine triggers a mechanism intended to lower very high blood sugar levels. However, this reaction negatively affects SIRT1, a protein critical to cell survival. A high concentration of glucosamine diminishes the level of SIRT1, leading to cell death in the tissues where this protein is abundant, such as the pancreas.

Individuals who use large amounts of glucosamine, those who consume it for long periods, and those with little SIRT1 in their cells are therefore believed to be at greater risk of developing diabetes. In a number of mammal species, SIRT1 level diminishes with age. This phenomenon has not been shown in humans but if it were the case, the elderly -- who constitute the target market for glucosamine -- would be even more vulnerable.

"The key point of our work is that glucosamine can have effects that are far from harmless and should be used with great caution," concluded Professor Picard.

The results obtained by Picard and his team coincide with recent studies that cast serious doubt on the effectiveness of glucosamine in treating joint problems.

This study was co-authored by Mathieu Lafontaine-Lacasse and Geneviève Doré.

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