- In 2010, multiple sclerosis at an earlier stage before permanent damage has occurred with 14,000 IU of Vitamin D3 given daily stopped the lesions in the brain that occurred late in summer and have been thought to be due to heat.
- Osteoporosis, Osteopenia, Osteomalacia (Softening of Bone, Fibromyalgia Pains) Doctors have made the mistake of recommending higher calcium supplements without greatly increasing the vitamin D3 dose because the widespread use of sunscreens blocked out UVB (burning rays) which produce vitamin D3 in our skin and stored in our fat tissues. The sunscreen essentially blocks out 100 percent of the UVB when the dermatologist keep suggesting that UVB blocks be increased over the last two decades and even be used during the winter leading to many illnesses including Osteoporosis.
A Nobel Prize was given to a doctor who found that the sun gives us enormous health benefits at the beginning of the Twentieth Century over 100 years ago. My we forget easily about this to make incredible profits treating illnesses.
The amount of vitamin D3 we produce in a bathing suit in the summer noon sun for 15 minutes in Los Angeles is equivalent to 20,000 IU of vitamin D3 in a pill!
As we need it, our body naturally releases Vitamin D3 from our fat cells. However, Obese people have so much fat that vitamin D3 is trapped in the fat. Double the dose is needed. When obese patients lost large amounts of weight, 100 percent of the people on Dr. Oz Show www.doctoroz.com were deficient.
Remember that physicians have to be very conservative in what they tell the public because they can be sued when the public over-does a recommendation as we always seem to do based on very little evidence. But we know from above that vitamin D3 is one thing that would be very difficult to overdose on. Yes, there was one account of a well known and popular Health Guru Gary Null in excellent health mistakenly took 1,000,000 IU of vitamin D3 daily for months. He survived, but we shall see if he recovers fully. http://pandemicsurvivor.wordpress.com/2010/08/06/extreme-vitamin-d-toxicity/
Dr. John Cannell, http://www.vitamindcouncil.org/news.shtml has studied the toxicity of vitamin D and is surprised how much can be taken with no deleterious health effects. See toxicity link in prior paragraph.
A coworker kept losing at least 20-30 pounds of weight, but he did not go see a doctor. I would have advised him not to get chemotherapy and if I had the knowledge then, 50,000 IU of vitamin D3 more than once a week. The best one can expect from the horrendous Chemo treatment is 5 years with 99 percent deaths. Could be the one percent was misdiagnosed and the Chemo did not kill them.
One way to cure all these problems? Eliminate tax subsidies to corporations and wealthy individuals with net-worth of over 5 million dollars. Greed has made us sicker.
I welcome any questions on vitamin D and health. I know quite a bit now and may be able to help you.
Jim Kawakami, Dec 12, 2010, http://jimboguy.blogspot.com
Pancreatic Cancers: A Slow Growing, but Difficult to Detect by Symptoms so Normally Fatal by the Time Detected http://www.vitamindhealth.org/2009/03/dr-holick’s-responses-to-participant-questions-during-the-december-5-2008-live-webinar-presentation-“vitamin-d-chronic-disease-risk”/#more-63 … How much Vitamin D would you recommend for a patient with pancreatic cancer who has a history of MS and is currently Vitamin D deficient?
Response: I treat all patients with vitamin D deficiency including patients with pancreatic cancer and patients with multiple sclerosis who are vitamin D deficient with 50,000 IU of vitamin D2 once a week for eight weeks followed by maintaining them on 50,000 IU of vitamin D2 once every two weeks thereafter to prevent recurrence of vitamin D deficiency.
The blood level of 25(OH)D is checked after the initial eight weeks to make sure that the patient has a blood level above 30 ng/ml. If not, then I will give an additional course of 50,000 IU of vitamin D2 once a week for the next eight weeks.
Then to prevent recurrence of vitamin D deficiency, I place the patient on 50,000 IU of vitamin D2 every two weeks thereafter. From our experience of six years, these patients typically have blood levels of between 40 and 60 ng/ml for 25(OH)D and there has never been any untoward toxicity in my patients following this program.
Vitamin D Levels to Prevent Cancer: Is it necessary to have vitamin D levels between 60-80ng/ml to prevent cancer?
Response: It does appear that when the blood level of 25(OH)D is at least 30 ng/ml that it may decrease risk of many deadly cancers. It is unknown, however, the blood level needs to be 60 ng/ml. There is no harm in keeping the blood level at between 60 and 80 ng/ml. I have all of my patients on enough vitamin D to maintain their blood levels between 40 and 100 ng/ml which I believe to be both therapeutic and preventative for chronic diseases including common cancers. … http://www.vitamindhealth.org/category/cancer/
Vitamin D deficiency will cause removal of both the calcium and matrix from the bone, and as a result, will cause osteopenia and can precipitate and exacerbate osteoporosis. Unlike osteomalacia which causes bone pain, osteoporosis, which is porotic bone, i.e., holes in the bones and loss of bone does not cause bone pain unless there is an acute fracture. Typically this pain resolves as the fracture heals and can be easily distinguished from osteomalacia.
Bischoff-Ferrari, HA, Giovannucci, E., Willett, W.C., Dietrich, T., and Dawson-Hughes, B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr 2006; 84:18-28.
Boonen S, Bischoff-Ferrari A, Cooper C, Lips P, Ljunggren O, Meunier PJ, Reginster JY. Addressing the musculoskeletal components of fracture risk with calcium and vitamin D: a review of the evidence. Calcif Tissue Int 2006; 78(5):257-70.
Chapuy MC, Arlot ME, Duboeuf F, Brun J, Crouzet B, Arnaud S, Delmas PD, Meunier PJ. Vitamin D3 and calcium to prevent hip fractures in elderly women. N Engl J Med 1992; 327(23):1637-1642. … http://www.vitamindhealth.org/category/osteoporosis/
Diabetes mellitus type II
The beta islet cells that produce insulin in the pancreas have a vitamin D receptor. The active form of vitamin D stimulates the pancreas to produce insulin. It has been observed that the relative risk of developing type II diabetes is reduced by as much as 33% in men and women who increase their intake of vitamin D above 800 IU/day along with 1,000 milligrams of calcium.
Pittas AG, Dawson-Hughes B, Li T, et al. Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care 2006:29:650-56. … http://www.vitamindhealth.org/2008/11/diabetes-and-vitamin-d/
It has long been recognized that patients with tuberculous do better when treated with vitamin D or exposed to sunlight. It was recently recognized that the immune cell known as the macrophage needs vitamin D in order to produce a peptide which is responsible for killing infectious agents such as tuberculous. It has been speculated that one of the reasons that influenza occurs in the winter time in tepid climates is because the sun is unable to produce vitamin D, and the resulting vitamin D insufficiency may promote and enhance the infectivity of the influenza virus.
Adams,J.S., Gacad,M.A., Anders,A., Endres,D.B., and Sharma,O.P. 1986. Biochemical indicators of disordered vitamin D and calcium homeostasis in sarcoidosis. Sarcoidosis 3:1-6.
Gallo, R.L., Eisenberg, D., Hewison, M., Hollis, B.W., Adams, J.S., Bloom, B.R., Modlin, R.L. 2006. Toll-like receptor Triggering of a vitamin D-mediated human antimicrobial response. Sciencexpress. 3:1770-1773.
Liu, P.T., Stenger, S., Li, H., Wenzel, L., Tan, B.H., Krutzik, S., Ochoa, M.T., Schauber, J., Wu, K., Meinken, C., Kamen, D.L., Wagner, M., Bals, R., Steinmeyer, A., Zugel, U. http://www.vitamindhealth.org/category/infectious-disease/
Obesity and Vitamin D
Obesity is associated with vitamin D deficiency. The reason is that the vitamin D is trapped within the fat and cannot easily exit. As a result, obese patients need at least twice as much vitamin D as a normal weighted individual in order to maintain a normal vitamin D status with a 25(OH)D between 30-60 ng/ml.
Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000;72: 690-693.
Rheumatoid Arthritis and Osteoarthritis
Recent studies have revealed that women who ingest more than 400 IU of vitamin D a day reduce their risk of developing rheumatoid arthritis by as much as 42%.
Vitamin D deficiency has been associated with an increased risk of developing osteoarthritis.
Merlino LA, Curtis J, Mikuls TR, Cerhan JR, Criswell LA, and Saag KG. Vitamin D intake is inversely associated with rheumatoid arthritis. Arthritis & Rheumatism 2004; 50(1):72-77 http://www.vitamindhealth.org/category/arthritis/