Friday, March 26, 2010

Coburn (R-OK) Stops Bill Preventing Medicare Pay CutsTaking Effect April 1

Tags: Coburn (R-OK), Stops Vote to Keep Medicare Payments for Doctors Dropping 21%, Trying to Stop Doctors from Treating Seniors

Please forward to all seniors and interested voters. Yes, definitely send it to your Republican friends.

Coburn (R-OK) Puts a Hold on Solving the Massive Medicare Pay Cut Which Will Take Effect April 1 and Can't Be Voted on Until April 12, who knows whether the Republicans will find another Senator to block it. In 2011, the Dems have a chance to change the Senate rules as Bush did in 2001 and threatened to invoke the Nuclear Option if ignoring the Senate Rules.

The Massive Medicare Pay Cut Will Take Effect April 1 and Can Be Only Reinstated on April 12th which is the time required for the block by Coburn (R-OK) to expire. Obama and the Democrats are trying to avoid what the Bush Republicans did during their eight years, have Democrats-generated deficits. So they are looking for ways to cut somewhere else.

The Republicans under Bush, Jr have been automatically cutting Medicare every year to destroy Medicare. The addition of the Big Pharma heavily subsidized Medicare D drug plan without paying for it was also added by Bush installed Supporting President of AARP who left after the deed was done. Also Bush lied about how much it cost, prevented revealing the true costs. It actually cost $200 Billion dollars more, but told the actuary to not say anything or he would be fired and ostracized.

Delay (R-Texas) who is still under indictment for breaking the law, lost the Medicare D in the normal 15 minute House, but kept the voting open for three hours to threaten and cajole those Republicans who voted against the bill for fiscal reasons without even knowing about the extra $200 billion in costs.

Now many doctors cannot afford to take on Medicare Patients. I had a hard time getting a doctor in Eugene, Oregon because Medicare pays Oregon doctors one-third what they pay the larger states.

The Republicans in Texas have made it impossible to sue doctors by packing the Supreme Court of Texas where Delay used illegal funds to get them elected. The Texans (R) then gerrymandered Districts in their state and got Supreme Court approval. A full Third of poor Texans have No Insurance or medicaid care, because they made it almost impossible or difficult for Texans to navigate through the difficult Texas requirements. I pity the poor Baby Boomers which is about half the whole Boomer population finding out that in Texas, who won't be covered until Medicare but if the Republicans take control again, they will find a way not to give benefits. Eventually Medicaid should be a National program because some states such as California and New York which make it easier to navigate the process, pay much more State portion of funds for Medicaid than Texas ever will.

But Doctors in McAllen, Texas get double the national average in Medicare payments by doing unnecessary procedures, while an equivalent population in a larger city gets the national average in payments.

Because most of the Mexicans lived on beans because they were too poor, the older ones are more healthy than typical Americans. Of course their younger generation because of High Fructose Corn Sugar are both Obese and Diabetic.

I am almost ashamed to get care from my low paid doctors and I gladly pay any bill they send me.
Now Senator Coburn, MD, (4-OK), one of the most radical Republicans and an Obstetrician who only takes care of young mothers and delivers babies, is also corrupt and advised Senator John Ensign (Nevada) on how to avoid the publicity of having sex with the pretty wife of one of his advisors by paying him $100,000 possibly from his campaign which is illegal even though he said his parents paid it off. Then he used campaign funds to pay off the husband in "severance" pay which is definitely illegal. He also lobbied to get the cuckold husband a job lobbying for someone else before the one year deadline which is also a crime. Ensign got all this advice from Coburn or most of it!

If you have a friend or family member, it is important to tell them if they are on Medicare or are considering voting for any Republicans. Except for Bush Sr, Right Wing Republicans have committed crimes during Reagan where Time magazine had page after page of head shots of Republicans who had to resign because of fraud. It was more than three pages and could have been around six.

But no one is even close to what Bush,Jr did during his 8 years. If justice prevailed he and his fellow Republicans should be put in jail including his lawyers who were exonerated by a Republican bought judge. http://www.medscape.com/viewarticle/719321?sssdmh=dm1.607762&src=ddd&uac=26057PR

Jim Kawakami, Mar 26, 2010, http://jimboguy.blogspot.com

March 26, 2010

Massive Medicare Pay Cut Will Take Effect April 1
In the name of fiscal responsibility, Sen. Tom Coburn, MD (R-OK), blocked a vote on a bill that would have extended the effective date of the 21.2% pay cut to May 1.
[read more]

Wednesday, March 24, 2010

How Democrats' Healthcare Bill will Affect Different People. News Media Now Anti-Obama?

Tags: military invades our lives, disaster capitalism, free lunch, Big Squeeze, Value of Nothing, Wealth of Nations, Healthcare Bill Effects

1. Why Wars? "The Complex: How the Military Invades Our Everyday Lives" by Nick Turse http://www.amazon.com/Complex-Military-Invades-Everyday-American/dp/0805078967/ref=sr_1_2?ie=UTF8&s=books&qid=1269468110&sr=1-2

2. Why Economic Roller Coasters? "The Shock Doctrine: Disaster Capitalism" by Naomi Klein" http://www.amazon.com/Shock-Doctrine-Rise-Disaster-Capitalism/dp/0312427999/ref=sr_1_1?ie=UTF8&s=books&qid=1269468236&sr=1-1

3. Why are Many of Us Working too Hard for Inadequate Wages and Why Government Cannot Reduce Our Taxes? "Free Lunch: How the Wealthiest Americans Enrich Themselves at Government Expense" (and Stick You With the Bill) by David Cay Johnston who was fired by the NY Times.

4. Why are even American Families in the Top 10-25% in Income Having a Tough Time? "The Big Squeeze: Tough Times for the American Worker" by Steven Greenhouse May have been fired by the NY Times. http://www.amazon.com/Big-Squeeze-Tough-American-Worker/dp/1400096529/ref=sr_1_1?ie=UTF8&s=books&qid=1269468436&sr=1-1

5. How was the unfettered Free Market Economics Sold to All of Us? The Value of Nothing: How to Reshape Market Society and Redefine Democracy" by Raj Patel Easy to Read Book on the Current Free Market Theory and How It was Sold to the Elites in the Neo Liberal Interpretation in the 1890s, the Time when the Robber Barons were in Charge to Make Corporations People with Special Privileges Not Given to Real People by Buying the Supreme Court as is the case now and Hired Economists to Alter What the Founder of Capitalism, Adam Smith, said about both Free Trade and the Worth of Labor. http://www.amazon.com/Value-Nothing-Raj-Patel/dp/1554686229/ref=sr_1_4?ie=UTF8&s=books&qid=1269468517&sr=1-4 (Try to get used copy. Jim)

6. The Complete and Unabridged Edition of "The Wealth of Nations" by Adam Smith and Introduction and Marvelous Index by Robert Reich, Labor Secretary for the Clinton Administration I have used Reich's marvelous expanded index to read about the lies that our dear Republicans and Greenspan has told us about the unregulated Free Market benefits. Actually Adam Smith said Bankers Must Be Regulated and Tells Us Why!

7. Raj Patel's (The Value of Nothing) shows his marvelous understanding of economic theories and even goes through philosophical theories of our Economic System in "The Great Transformation: The Political and Economic Origins of Our Time" by Karl Polanyi with a marvelous New Introduction by Nobel Laureate Joseph E. Stiglitz and a new introduction by Fred Block. Polanyi is the favorite economic philosopher of George Soros, one of our great investors and also one of greatest donators to social causes all over the world. He is always ahead of the Wall Street's Herd of Lemmings.

Fred L. Block is an American sociologist, and Professor of Sociology at the ... Block has served on the Board of the Karl Polanyi Institute of Political ...
en.wikipedia.org/wiki/Fred_L._Block - Cached - Similar

"One of the most important and original works of this century."
by Robert Kuttner
Kuttner is the co-founder and current co-editor of The American Prospect, ... Robert Kuttneris author of several books dealing with economic and labor ...
en.wikipedia.org/wiki/Robert_Kuttner - Cached - Similar

Published: March 24, 2010

How Different Types of People Will Be Affected by the Health Care Overhaul


NY Times: Not on Web Front Page (That is why I subscribe to the paper edition. Hard to find things online that we do not know about due to Editor Choice on What is Important. Blog by Tara Parker-Pope has it, but not most popular so if you did not read the blogs, you might have missed this one. It is important to read them from your favorite writers including Krugman. Because they are under less editorial control who might change the title to make them more obscure. Our local Register Guard does put an appropriate title to his columns and to stories by the New York Times.

Few realize that all the front page stories and headlines are prepared by the Editors and first six paragraphs are often selected by the editor and many times does not convey the most important reason why the reporter wrote the article. About half are Propaganda Pieces since before 1928 when Edward Bernays published his book "Propaganda" which is now in paperback and has a great introduction by Krispin Miller

(These are the biggest gripe by reporters not expressed publicly, but I have read books by retires NY Times reporters and editors who point this out. Go to most popular page Which covers most e-mailed, most blogged about, and most searched. None covered it. Jim)

  1. Mark Crispin Miller - Wikipedia, the free encyclopedia

    Mark Crispin Miller is professor of media studies at New York University and the author of the book: Fooled Again, How the Right Stole the 2004 Elections. ...
    en.wikipedia.org/wiki/Mark_Crispin_Miller - Cached - Similar
  2. News From Underground

    Mar 24, 2010 ... News From Underground is a daily e-news service run by Mark Crispin Miller, a Professor of Culture and Communication at NYU. ...
    markcrispinmiller.com/ - 2 hours ago - Cached - Similar
CNN has A FORMER AIPAC, Israel's lobbying arm giving us the most political news about Israel and threatens politicians to favor Israel's now Right Wing failed policies for the security of Jews worldwide. Who? Wolf Blitzer, who worked for the Israelis and was a member of AIPAC. Niall Ferguson who wrote about the origins of money said on PBS that in the Financial Panic of 1873, Jews were targeted for violence and hatred. I am concerned that our media concentrating on Goldman Sachs and not JP Morgan too as the perpetrator of the financial markets were they got special deals from Republican Sec of Treasury Paulson and only by the Obama administration only because financial collapse of our Credit Market with many Money Markets unable to give their money back including many towns and cities was starting to happen. They had no time to wait.

March 15, 2010

ANNALS OF ECONOMICS

No Credit
ANNALS OF ECONOMICS about Treasury Secretary Timothy F. Geithner…
by John Cassidy (Personal Interview shows how strong and smart Geithner was in not going with the crowd including Obama and Summers at the White House.)Read more: http://www.newyorker.com/search/query?query=authorName:%22John%20Cassidy%22#ixzz0j8Fb0ZhG

Note that really important propaganda pieces are often primarily written by reporters who rarely report for the New York Times and use someone like Risen as a subordinate co-author. White Water and over charged Lewinsky scandal. Obermann, who quit MSNBC during the Lewinsky Scandal because he refused to report on this travesty when the Republicans were doing far worst adulterous relationships is now the star of the MSNBC news team along with Rachel Maddow at http://countdown.msnbc.com and http://rachel.msnbc.com respectively has given us more centrist news instead of center-right or sometimes far right on FOX and Now on CNN.

Not many noticed that ABC fired a lot of reporters from the ABC News. I have seen the local ABC local news the most liberal now in Eugene giving us National Right Wing rhetoric only! The local CBS news uses the same theme as Fox Cable to present how Democratic politicians are failing.

  1. ABC News Layoffs Expected: Memo Says Cuts Part Of 'Transformation'

    Feb 23, 2010 ... A heavy round of ABC News layoffs is expected to begin soon as part of a major network transformation. Up to 20 percent of the news division ...
    www.huffingtonpost.com/2010/.../abc-news-layoffs-expected_n_473778. html - Cached
  2. ABC News Plans to Cut Staff by 300 to 400 - NYTimes.com

    Feb 24, 2010 ... Published: February 23, 2010. ABC News will sharply reduce its news-gathering staff through buyouts and possible layoffs, the company said ...
    www.nytimes.com/2010/02/24/business/media/24abc.html
  3. Boeing Sends More Than 1000 Layoff Notices - ABC News

    Feb 8, 2010 ... Boeing sends more than 1000 layoff notices, mostly tech workers in Washington and California. CHICAGO February 19, 2010 (AP) ...
    abcnews.go.com/Business/wireStory?id=9888958

Published: March 24, 2010

How Different Types of People Will Be Affected by the Health Care Overhaul

On Tuesday, President Obama signed into law a sweeping overhaul of the nation’s health care system, approved by the Senate on Christmas Eve and by the House on Sunday. The House also adopted a package of changes — agreed to in negotiations among House and Senate Democrats and the White House — which is being considered by the Senate. The legislation will tighten regulation of insurance companies and is expected to extend medical coverage to more than 30 million uninsured Americans. While it is impossible to gauge the precise impact of the overhaul, since many options vary by location, below are some of the main ways the overhaul will affect certain types of households. ... http://www.nytimes.com/interactive/2010/03/24/us/politics/20100319-health-care-effect.htm#tab=5

Sunday, March 21, 2010

Use Sunscreen Only for Face and Expose Sun on Arms and Legs as Much as Possible without Burning to Build-Up Vitamin D

Tags: Sunscreen Use, Vitamin D Uptake, How Much?, Dermatologists

Dr. Michael Holick is one of the few that have said that Dermatologists are heavily invested with the Cosmetics Industry!

Is that why they push sunscreen so much? Like all of us, good looking personable representative of the cosmetics industry can easily fool all of us. The top lobbyists for the Health Insurance company is really good. She is not only attractive, but also very intelligent, very personable, and can answer every objection about them with ease.

Our emotional brain by-passes our thinking brain.

Jim Kawakami, March 23, 2010, http://jimboguy.blogspot.com

Vitamin D is Called the Sunshine Vitamin for Good Reason

Michael F. Holick, PhD, MD
Professor of Medicine, Physiology and Biophysics
Director of the General Clinical Research Center
Director of the Vitamin D, Skin and Bone Research Laboratory
Director, Biologic Effects of Light Research Center
Boston University Medical Center

http://www.vitamindcouncil.org/scientists.shtml Lists of scientists on Vitamin D research. Holick is one of these.

Vitamin D is not a vitamin but a hormone. It is unique in that it is made in the skin as a result of exposure to sunlight. Photosynthesis of vitamin D has been occurring on earth for more than 750 million years. Some of the earliest life forms that were exposed to sunlight for their energy requirement were also photosynthesizing vitamin D. Both children and adults have in the past depended on adequate sun exposure to satisfy their vitamin D requirement. It is well documented that at the turn of the last century upwards of 80% of children in the industrialized, polluted cities of northern Europe and northeastern United States suffered from the devastating consequences of vitamin D deficiency rickets. The skin has a large capacity to make vitamin D. Exposure of a person in a bathing suit to a minimal erythemal dose of sunlight, which is typically no more than 15-20 minutes on Cape Cod in June or July at noon time, is the equivalent to taking 20,000 IU of vitamin D orally. It is now well documented that in the absence of any sun exposure 1,000 IU of vitamin D3 a day is necessary to maintain healthy levels of 25-hydroxyvitamin D in the circulation. An analysis of the NHANES III data has demonstrated that neither children nor adults are receiving an adequate amount of vitamin D from their diet or from supplements. ... http://www.vitamindhealth.org/?p=3#more-3

QUESTIONS FOR DR. MICHAEL HOLICK

Dr. Sunshine

Dermatologists have gone so far as to recommend that you should never walk outside without a sunscreen. The American Academy of Dermatology still has that recommendation that you should never be exposed to one ray of direct sunlight without sun protection.

Why do they say that?
They are heavily invested, I think, with the cosmetics industry. The American Academy of Dermatology just had their annual meeting in Miami Beach. It was huge. Many of the major cosmetic companies were there, and they were spending thousands of dollars just to be out there and promote their products to the dermatologists.

Why would the anti-sun academy hold its annual meeting in Miami Beach, the sun capital of the East?
That kind of says it all. They still seek the sun, just like everyone else.

How long does one need to stay in direct sun to absorb 2,000 I.U. of D, your ideal daily dose?
You don’t absorb it. You make it. In the spring, I recommend about 15 to 30 minutes on your arms and legs two to three times a week.

What if you would rather be dead than walk around New York in gym shorts? Why is exposing your legs so important?
There’s the rule of 9s. You have about 18 percent of your skin surface on each of your legs. Your face is only 9 percent; we never recommend you expose your face. You should always protect it with either sunscreen or an appropriate hat.

In 2004, you were fired from Boston University’s department of dermatology by Dr. Barbara Gilchrest, who was head of the department.
She called me into her office and said that she couldn’t have somebody in her department recommending sun exposure.

At the time, she also questioned whether your findings had been compromised by money you received from the tanning industry. You received research money from the Indoor Tanning Association.
That’s not true. The money came from the UV Foundation, a nonprofit arm of the Indoor Tanning Association.

You’re still at Boston University, where you run the vitamin D lab, right?
We’ve been looking at prostate and colon cancer and showing that if you give mice vitamin D, it reduces tumor growth by as much as 40 percent to 50 percent

What bothers me about your research is the inflated claims you make for it. You say that one pill can prevent and treat everything from cancer to autism to depression. There has never been a medication that did all that.
I never said autism.

It’s on the cover of your book!
O.K. There has been an association between vitamin D deficiency and autism. More studies need to be done. What I recommend certainly is that autistic children receive vitamin D, because it improves muscle function.

Do any vegetables contain vitamin D?
It turns out, curiously, that mushrooms contain vitamin D. Then, of course, there are the fortified foods, which are principally the dairy products with 100 units of vitamin D per serving.

Which is why our mothers made us finish our milk. It sounds as if it is almost impossible to get enough D in one’s daily diet through food alone.
The bottom line is that everybody should be taking a supplement. I do it, even though I’m out there cycling for an hour or two without sunscreen on my arms and legs.

In that case, you should be checked for melanoma. Do you have a dermatologist?
No. I don’t have wrinkles. I do a skin survey on myself every couple of months just looking in a mirror.
INTERVIEW HAS BEEN CONDENSED AND EDITED.

How to Be Brilliant

... Now here comes David Shenk with “The Genius in All of Us,” which argues that we have before us not a “talent scarcity” but a “latent talent abundance.” Our problem “isn’t our inadequate genetic assets,” but “our inability, so far, to tap into what we already have.” The truth is “that few of us know our true limits, that the vast majority of us have not even come close to tapping what scientists call our ‘un actualized potential.’ ” At first it would seem that Shenk, the author of thoughtful books on information overload, memory loss and chess, has veered into guru territory. But he has assembled a large body of research to back up his claims.

Two bodies, in fact. The first concerns the emerging science of epigenetics, the study of how the environment modifies the way genes are expressed. Since the days of Crick and Watson, we’ve tended to see genes as a set of straightforward instructions, a blueprint for constructing a person. Over the last 20 years, however, some scientists have begun to complicate that picture. “It turns out that the genetic instructions themselves are influenced by other inputs,” Shenk writes.

“Genes are constantly activated and deactivated by environmental stimuli, nutrition, hormones, nerve impulses and other genes.” That means there can be no guaranteed genetic windfalls, or fixed genetic limits, bestowed at the moment of conception. Instead there is a continually unfolding interaction between our heredity and our world, a process that may be in some measure under our control.

The second body of research investigates the nature of exceptional ability and how it arises. We’ve traditionally regarded superior talent as a rare and mysterious gift bequeathed to a lucky few. In fact, Shenk writes, science is revealing it to be the product of highly concentrated effort. He describes the work of the psychologist Anders Ericsson, who wondered if he could train an ordinary person to perform extraordinary feats of memory.

When Eric sson began working with a young man identified as S.F., his subject could, like most of us, hold only seven numbers in his short-term memory. By the end of the study, S.F. could correctly recall an astonishing 80-plus digits. With the right kind of mental discipline, Ericsson and his co- investigator concluded, “there is seemingly no limit to memory performance.” Shenk weaves accounts of such laboratory experiments, conducted on average people, with the tales of singularly accomplished individuals — Ted Williams and Michael Jordan, Mozart and Beethoven — who all worked relentlessly to hone their skills. ... http://www.nytimes.com/2010/03/21/books/review/Paul-t.html


Friday, March 19, 2010

Animal Studies Indicate Vitamin D can Deplete Vitamin K at Toxic Levels. Warfarin Users Need to Be Especially Careful by Tests

TAGS: Vitamin D Studies: Animal studies Vit D Depletes Vit. K, Lowers Death Lung Cancer, Helps Fractures


George and Art,

I assume you get your vitamin K checked routinely with Warfarin use. First if you have a low level of vitamin D level by measuring 25 hydroxy-Vitamin D metabolite in your book, you will need to take supplements of vitamin D or carefully monitor how much strong sun time you should need. Animal studies, especially rat ones do not prove out, but why take a chance. Vitamin K levels should be checked by your physician in doing your metabolic and comprehensive Blood and urine tests. I also recommend Cytokine Reactive Protein Test called C-Reactive Protein Test at least once a year or more to detect inflammation anywhere in your body. The inflammation is necessary for cancer to spread. Don't let your doctor talk you out of it. Both cancer and heart disease produces Cytokine Proteins, so they may be detected earlier than the cancer itself.

One International Unit or IU is equivalent to .025 micrograms http://www.dietpower.com/help/glossary/international_units_of_vitamin_d.htm

To convert IUs of vitamin D into micrograms: multiply the number of IUs by 0.025. The result is the number of micrograms in the food.

To convert micrograms to IUs: multiply the number of micrograms by 40. The result is the number of IUs in the food. 20 micrograms equals 800 IU.

According to a Harvard study 50,000 IU of Vitamin D appears safe when given to patients low in vitamin D. Since our body stores the vitamin D for up to three months, and then the same done every other week, I would assume that getting vitamin D with sunlight is probably the safest way to get it except for possibly those who have low vitamin K such as Warfarin users. Warfarin is monitored in patients fairly often. I assume they check for vitamin K, a clotting agent in the blood to prevent users from bleeding.

Vitamin A taken with Vitamin D helps preserve vitamin K.

I am not sure what to advise you. Most of us do take vitamin A in our multi-vitamins, but your health is important and those who not take Warfarin should have their vitamin K and clotting time at least once a year and more often if you jumped in the use of vitamin D. I now use a total including all supplements of 4,600 IU daily taken half in the morning and the rest after supper.

I will check my tests to seem if I did a vitamin K test. I take lots of fish oil which thins out my blood, but I do not seem to bleed excessively. As we become older, seeing your doctor more often during the year is exactly what I have done. Sometimes illness hits us unexpectedly, but tests might catch the cause much earlier.

Jim Kawakami, Mar 19, 2010, http://jimboguy.blogspot.com




CONTENTS:

Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe.

Lung Cancer Survival and Exposure to Sunlight Among Norway's Young Males
Novel Understanding that Vitamin D Exerts Toxicity by Inducing a deficiency of Vitamin K. (Animal Studies)


Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe.

BMJ. 2010; 340:b5463 (ISSN: 1468-5833)


OBJECTIVES: To identify participants' characteristics that influence the anti-fracture efficacy of vitamin D or vitamin D plus calcium with respect to any fracture, hip fracture, and clinical vertebral fracture and to assess the influence of dosing regimens and co-administration of calcium. DESIGN: Individual patient data analysis using pooled data from randomised trials. DATA SOURCES: Seven major randomised trials of vitamin D with calcium or vitamin D alone, yielding a total of 68 517 participants (mean age 69.9 years, range 47-107 years, 14.7% men).

STUDY SELECTION: Studies included were randomised studies with at least one intervention arm in which vitamin D was given, fracture as an outcome, and at least 1000 participants.

DATA SYNTHESIS: Logistic regression analysis was used to identify significant interaction terms, followed by Cox's proportional hazards models incorporating age, sex, fracture history, and hormone therapy and bisphosphonate use.

RESULTS: Trials using vitamin D with calcium showed a reduced overall risk of fracture (hazard ratio 0.92, 95% confidence interval 0.86 to 0.99, P=0.025) and hip fracture (all studies: 0.84, 0.70 to 1.01, P=0.07; studies using 10 microg (400 IU) of vitamin D given with calcium: 0.74, 0.60 to 0.91, P=0.005). For vitamin D alone in daily doses of 10 microg or 20 microg, no significant effects were found. No interaction was found between fracture history and treatment response, nor any interaction with age, sex, or hormone replacement therapy.


Lung Cancer Survival and Exposure to Sunlight Among Norway's Young Males

CONCLUSION: This individual patient data analysis indicates that vitamin D given alone in doses of 10-20 microg is not effective in preventing fractures. By contrast, calcium and vitamin D given together reduce hip fractures and total fractures, and probably vertebral fractures, irrespective of age, sex, or previous fractures. ... http://www.medscape.com/medline/abstract/20068257?cid=med&src=nlbest

Lung Cancer. 2007; 55(3):263-70 (ISSN: 0169-5002) … Our results indicate that season of diagnosis is of prognostic value for lung cancer patients, with a approximately 15% lower case fatality for young male patients diagnosed during autumn versus winter (RR=0.85; 95% CI, -0.73 to 0.99; p=0.04). Residing in a high UV region resulted in a further lowering of the death risk than residing in a low UV region. We propose, in agreement with earlier findings for prostate-, breast- colon cancer and Hodgkins lymphoma, that a high level of sun-induced 25-hydroxyvitamin D can be a prognostic advantage for certain groups of lung cancer patients, notably for young men.

Lung cancer has for several decades been the leading cause of cancer-related mortality in men in Norway and during the last two decades, became the second most common cause of cancer-related death in women . There are two main types of lung cancer: small cell lung cancer for which chemotherapy is the primary treatment and non-small cell lung cancer, which in its early stages is treated primarily with surgery. Gender-related differences have been described in the literature with respect to survival after therapy, male gender being a significant independent negative prognostic factor .

In Norway the 5 years relative survival for localized tumours is about 30% for females and 20% for males. Calcitriol, which is the most active form of Vitamin D, is involved in key regulatory processes such as proliferation, differentiation and apoptosis in a wide variety of cells . Mechanisms for these actions have been proposed to be the interaction of active Vitamin D derivatives with a specific nuclear receptor (VDR receptor) and/or with membrane targets . ... http://www.medscape.com/medline/abstract/17207891

Novel Understanding that Vitamin D Exerts Toxicity by Inducing a deficiency of Vitamin K. The dose of vitamin D that some researchers recommend as optimally therapeutic exceeds that officially recognized as safe by a factor of two; it is therefore important to determine the precise mechanism by which excessive doses of vitamin D exert toxicity so that physicians and other health care practitioners may understand how to use optimally therapeutic doses of this vitamin without the risk of adverse effects.

Although the toxicity of vitamin D has conventionally been attributed to its induction of hypercalcemia, animal studies show that the toxic endpoints observed in response to hypervitaminosis D such as anorexia, lethargy, growth retardation, bone resorption, soft tissue calcification, and death can be dissociated from the hypercalcemia that usually accompanies them, demanding that an alternative explanation for the mechanism of vitamin D toxicity be developed.

The hypothesis presented in this paper proposes the novel understanding that vitamin D exerts toxicity by inducing a deficiency of vitamin K. According to this model, vitamin D increases the expression of proteins whose activation depends on vitamin K-mediated carboxylation; as the demand for carboxylation increases, the pool of vitamin K is depleted.

Since vitamin K is essential to the nervous system and plays important roles in protecting against bone loss and calcification of the peripheral soft tissues, its deficiency results in the symptoms associated with hypervitaminosis D.

This hypothesis is circumstantially supported by the observation that animals deficient in vitamin K or vitamin K-dependent proteins exhibit remarkable similarities to animals fed toxic doses of vitamin D, and the observation that vitamin D and the vitamin K-inhibitor Warfarin have similar toxicity profiles and exert toxicity synergistically when combined. ...

toxic doses of vitamin D, and the observation that vitamin D and the vitamin K-inhibitor Warfarin have similar toxicity profiles and exert toxicity synergistically when combined.

The hypothesis further proposes that vitamin A protects against the toxicity of vitamin D by decreasing the expression of vitamin K-dependent proteins and thereby exerting a vitamin K-sparing effect. If animal experiments can confirm this hypothesis, the models by which the maximum safe dose is determined would need to be revised. Physicians and other health care practitioners would be able to treat patients with doses of vitamin D that possess greater therapeutic value than those currently being used while avoiding the risk of adverse effects by administering vitamin D together with vitamins A and K. http://www.medscape.com/medline/abstract/17145139