Showing posts with label epigenetics. Show all posts
Showing posts with label epigenetics. Show all posts

Tuesday, March 16, 2010

Glenn Close Starring in FX Damages is Having Her Complete DNA Genome Done. Republican Jihad

Tags: Glenn Close's Genome Done, Actresses Little Crazy, Gates, Epigenetics, Republican Jihad, How Republicans Ruined Us
I met some future actresses at UCLA and an Opera singer in New York and her many friends at a party. Most are in therapy and my impression was that what makes them good actors and survive the incredible competition and disappointments in show business is being a little crazy. They were not boring! On average good actors and opera singers were quite intelligent and certainly not average.

Professor Gates of Harvard showed on P
BS that complete DNA sequencing seems to work well because apparently lots of the so-called junk DNA has an influence on diseases even though no genes are located there. We can only assume that they do influence which genes are active or not.

The recent decade of scientific studies has shown that environmental influences such as famines or constant wars allows the survival of those who have the right genes turned off or on or have a genetic change in both the active and gene located genome.

So the sociologists who have long claimed that our environment does influence our behavior were right, but not in the way they thought. The premise that genes influence our behavior has been largely correct, but they neglected the influence of our environment in determining which genes are off or on, called Epigenetics. The evolution of the fairly recent science of Epigenetic effects which simply can be explained as genes being turned off or on depending on their environment and can be transferred through generations unless the environment or influences change. Even now identical twins which have the same DNA can have different illnesses if their environment is quite different and one will get cancer and the other will not. We have a cancer suppressor gene which if turned off makes us more susceptible to cancer.

Excerpt of Glenn Close article: ... "For me, anything that can move the science forward is worthwhile," Close said in a telephone interview. "It's pretty well publicized that I have mental health issues in my family."

Close, whose family illnesses include bipolar disorder and schizophrenia, is a founder of the nonprofit group BringChange2Mind, which raises awareness about mental illness.

New sequencing technologies through companies like Illumina of San Diego, which did Close's genome, have vastly reduced the cost of producing an entire map of the human genome -- essentially the genetic recipe that makes up an individual.

Whereas the first human genome cost $3 billion and took more than a decade to produce, Illumina charges $48,000 for the kind of sequencing Close got. The company would not say whether it charged her. (Of course it was free! Jim)

Scientists say even newer technology will bring the price down to $1,000 within five years, essentially less than the cost of an advanced type of X-ray called a CT scan. ... (Don't get a CT scan lightly. The dose of X-Rays is extremely high compared to chest x-rays. Over the past year a huge overdose and deaths in New York resulted from software errors have even killed a few people we know about. Cancers take more time to surface. Jim)

Reuters Julie Steenhuysen Mar 11, 2010 ... Close, who stars in the FX television series "Damages" and is known for movie roles including "Fatal Attraction" and "Dangerous Liaisons," said the offer was too good to pass up. ...
http://www.newsdaily.com/stories/tre62a5p6-us-genome-close/

Jim Kawakami, Mar 16, 2010, http://jimboguy.blogspot.com

Americans Have Very Short Term Memory and Have Largely Forgotten the Gut Erupting Scare We Had in 2008, thanks to the Free Market and Republican Ideology. Let Me Remind You.

Since the 1980s or Reagan Era and radical Bush Era, many new epidemics such as Alzheimer's Disease, Autism, and other neurological diseases have mushroomed, many due to inadequate testing of drugs and products. Dementia, for example, has been shown to be due to some drugs, not adequately tested for all effects on us. Read "Our Daily Meds" Introduction of sunscreens with only a UVB block which led to the melanoma epidemic even in Sweden!

1. More sickness and death from deadly bacteria in our foods and on our skin

Introduction of anti-bacteria soaps which killed good bacteria and left the deadly ones such as MRSA that has killed many people.

I don't know this for sure that MRSA is caused by this mechanism, but E-Coli poisonings in our kitchen resulted from sterilizing the kitchen counter with anti-bacterial sprays which did the same thing. The article in the Journal of the American Medical Society about a decade ago reported this. Dr. Oz, ABC, said that many do not realize that anti-bacterial soaps kill the good bacteria and do a poor job in killing the more deadly ones. Do not use anti-bacterial soaps. I only survived boils all over my body with many open sores because I avoided anti-bacterial soaps based on my knowledge that malaria bacteria and insects mutate by a natural selection process where the strong unusual ones survive while the normal bacteria and insects die.

2. More deaths and recalls of drugs during the 8 year Bush regime due to marketing controlled FDA. For example Viagra and deadly Diabetes drugs were introduced. There were many others recalled and many not recalled yet, all from the Bush Administration.

3. We got an exponential rise in asthma due to increased real pollution due to telling companies they can increase production without installation modern pollution abatement equipment, something required by law! Not many know during the Bush years carbon dioxide rate of increase doubled going from one percent a year to two percent due to extensive coal plants being produced. China puts out as much carbon dioxide as we do even though on an individual use basis it is much lower than us. They have relied on Coal which produces twice as much carbon dioxide as we do due to the developed world such as the USA shipping production to China so they could pollute to their hearts desire.

4. White Collar has increased exponentially including politicians and lobbyists during the Bush regime including Wall Street/Bankers collapse of our financial system. Not many remember that Bush essentially got rid of the White Collar crime unit in the FBI. That is why White Collar crimes is rampant now even from places such as Russia and Nigeria. I get fake e-mails from my e-mail list more often than in the past.

  1. TruthOrFiction.com-Is that forwarded email Truth or Fiction ...

    The home of TruthOrFiction.com, the place to check out forwarded emails to see whether they are hoaxes, urban legends, scams, myrban myths, or the truth.
    www.truthorfiction.com/ - Cached - Similar
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    Hoax-Slayer keeps you informed about the latest email hoaxes, true email ..... that clearly indicate if the claims in the message are true or false. ...
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    I know when the Clintons left the White House, the Veterans Administration was being compared with the Mayo Clinic which Bush dismantled, FEMA was sensational after fixing a disposable FEMA by Bush, Sr. which Bush Bush cut sharply and put in an incompetent Horse Trainer as head, the same happened to our FDA which is supposed to protect us and changed the law so that the FDA only gets money to do research on drugs from Big Pharma and installed the head of Marketing at Monsanto to allow the distribution of genetically modified foods GMO without checking their safety.
In the Republican Nixon administration Secretary of Agriculture Butz (R) made a revolution decision to change what Americans eat by deciding to put in the subsidies to give us our Food Distribution System, and subsidize corn to the hilt and allow the monopolization of our food industry where only five companies control all we eat! This led to many of the illnesses suffered by Americans now.

a. Essential all our diet in prepared foods is based on fast grown genetically modified corn and soybeans stripped of nutrients in native corn. Almost all our deadly high fructose corn sugar and syrup is made from corn. Have the harvest is used for making this Fructose sugar.
b. Some books which are must reads are:

Food Rules (2009) and Omnivore's Dilemma by Michael Pollan, 2006 both on NYT Best Sellers in Paperback Now

Publisher's Weekly: ... He starts with a McDonald's lunch, which he and his family gobble up in their car. Surprise: the origin of this meal is a cornfield in Iowa. Corn feeds the steer that turns into the burgers, becomes the oil that cooks the fries and the syrup that sweetens the shakes and the sodas, and makes up 13 of the 38 ingredients (yikes) in the Chicken McNuggets.Indeed, one of the many eye-openers in the book is the prevalence of corn in the American diet; of the 45,000 items in a supermarket, more than a quarter contain corn. Pollan meditates on the freakishly protean nature of the corn plant and looks at how the food industry has exploited it, to the detriment of everyone from farmers to fat-and-getting-fatter Americans. ...

Stuffed & Starved: The Hidden Battle for the World Food System by Raj Patel, 2007 "How can starving people also be obese?" Why does everything contain soy? "What's the relationship between petrochemicals, biofuels, and the price of food?

One of the most dazzling books I have read in a very long time. The product of a brilliant mind and a gift to a world hungering for Justice. Naomi Klein, author of No Logo and The Shock Doctrine: Disaster Capitalism

"For anyone attempting to make sense of the world food crisis, or understand the links between U.S. farm policy and the ability of the world's poor to feed themselves, Stuffed and Starved is indispensable," Michael Pollan (The Republicans put in a law that makes it a crime to criticize beef! Remember Oprah said on her that she will never eat hamburgers again after her discussion with guests about e-coli killing still more Americans. She was in a huge lawsuit in Texas where those less wealthy would have lost.

The recent film about corn and food production had to be stripped of many good things to allow the producer to distribute the film in America. Just like information readily available in Europe, Japan, and yes, China about food and politics, America has the most manipulative press/media in the world. I noticed that MSNBC had guests and commentators criticizing the Health and Finance Bill from the Left while the Republicans criticize it from the FAR RIGHT.

Commentators, Politicians, and Book Authors are invited on TV to give their opinions. Yes, corporations can use someone who is on our side to fool us. They are doing it now with Kucinich and Michael Moore who want perfection and just talk about what is not in the bill and not what is in the bill that would help Americans greatly. So what is we have to wait a few years to fit our current budgets.

Even some people we trust do not know about how absolutely helpful the current Heathcare and Financial bills will be. When a amateur such as myself knows more than many who talk to us, I have to suspect they have an agenda.

With very clever propagandist involved in advertising and news, they give us what they want us to think. Why do we buy stuff we never use much or at all? Advertising! Why do we use medications that can kill or harm us. Advertising. The most important parts of propaganda is to present someone who looks trustful to give you the facts in the book "Trust Us We're Experts" . Both the Wall Street Journal and New York Times' front page have half the story giving us propaganda. This has been true for a long time. The way that propaganda works is they tell us lots of truth along with the lies to make us believe them. Lies by deletion is quite common. As the Republican Propaganda station FOX Cable said, if they don't report it, it never happened.

Even someone with the credentials of Michael Moore has inaccurate or incomplete information of both the Healthcare Bill and Financial Regulation Bill. Lucky for us MSNBC also presents views from knowledgeable congressmen and congresswomen such as Anthony Weiner (D-NY) and Debbie Wasserman Schultz (D-FL) and Frank Barney (D-MA) for financials. If you read the whole article and dismiss the headlines and first few paragraphs, the New York Times is a good source too.

Legacy of Corporate Republicans and Some Democrats who voted on Republican Financial Bills such as in 1999 and 2000 which led to the collapse of our financial system. Remember it was a Bond Crisis as Lewis reminded us on http://rachel.msnbc.com .

Bond trading is where the crooks are because it is done in secret by big traders who charge you what the market can bear in fees. Don't be a sucker and do your own investing. We do not know enough and trading is based on rumors or special information. I favor index funds world-wide because even though have lots of those smart people who tells us to invest in this or that long-after the market went up 40% on average so they can sell into a buyers market. These guys don't make money based on performance on the whole, but from fees, many of which are not reported. Why is lying to us not illegal?

My advisor who worked at Smith-Barney, now part of Morgan Stanley, quit when she would not hawk bad stocks they wanted to get rid of as often done at the Wall Street Firms. She does not trust the best bond trader of the decade from PIMCO. I won't name him but you can probably guess. He was telling us to change strategy, a change he made many months ago and just basically what others have said for the last six months. But he is GOD so who can doubt his advice? http://wealthtrack.com/previous.php

A neighbors daughter fresh into Wall Street made millions in Wall Street trading bonds in the 1980s in just a few years. Lewis said he made money by doing practically nothing as a freshman on Wall Street of $200,000 which was a lot of money at that time! Of course he was quite good, but what did their investors get? The shaft?

Better detection methods does not explain a six-fold increase in Autism in California in the 1990s, for example. More sickness and death from bacteria in our foods, more drugs recalled verses the Clinton era, more White Collar Crimes such as the one the lead to the S&L crisis in the 1980s, the Republican led dismantling of Financial Regulations involving the Bush family.

More people are losing their health insurance and going bankrupt because of expenses half with insurance and loss thereof when people could no longer work and lose their jobs, the huge acceleration of toxic prepared foods in our Fast Food joints, restaurants, and frozen food section of our supermarkets.

Jim Kawakami, Mar 16, 2010, http://jimboguy.blogspot.com



Friday, October 23, 2009

Frank Schaeffer, Founder of the Religious Right, Speaks Out Against FOX News Vicious Untrue Comments

Frank Schaeffer's books and lectures gave the Right Wing the theoretical basis for justifying the actions of the Religious Right including even murder by directing them to select contradictions in the Old Testament and ignoring Jesus' Teachings. Republican Gomorrah by Max Blumenthal interviewed the major leaders in the Right Wing and dug into how their personalities and paranoia led to our current religious leaders including the recently deceased Falwell.

I found it very disturbing that almost crazy people with no Christian Ethics are running the disciples of the Religious Right. Schaeffer's teachings misinterpreted or extrapolated led to radicals and crazies who elected the most radical Republicans in their primaries and won elections by using smear tactics and lies with money from multimillionaires and billionaires who wanted to use them for profit and to enhance their wealth and power.

Recent research has shown those who were born in crowded cities became Schizophrenic at more than twice the rate of the general population. Apparently New York City has about 30 percent of the residents in need of psychological or psychiatric care. Those who grew in less conflicted homes are much more sane. Here is a case finally published after many rejections by establishment journals when race is mentioned as an important factor in mental illness with Caribbean Blacks having many more cases of Schizophrenia than the rest of the British population. African based people's in all income brackets seem to have a higher rate of Schizophrenia although no genetic basis has been established.

The researchers have determined that Epigenetic environmental factors over-write the genes by controlling whether the genes are off or on as we have seen many times among identical twins with one prone to cancer and the other not. Stress, for example, causes one identical twin to have many more wrinkles than her sister.The November 2009 Scientific American has a short summary of these results. http://discussion.pbs.org/viewtopic.pbs?t=79040

It is well known that Ireland has a very high rate of Schizophrenia. I suspect most of it is in Northern Ireland where many Scot-Irish who immigrated to the USA South and further spread into the mid-west and California's Orange Country. This probably accounts to some extent to their radical Republican view of the world. Mental illness, I suspect, is not an off or on thing but a gradation to insanity like some of those at FOX news and especially the House Republicans.

Even before he had the final clarity, Schaeffer became increasingly disturbed by the people attracted to his teachings. In Geneva, Switzerland, his colony was somewhat akin to a Hippie colony and even attracted Bono and homosexuals. Schaeffer called Falwell stupid and Robertson crazy in his interviews with Max Blumenthal in "Republican Gomorrah," a book well worth reading to understand the Republican Right.

Jim Kawakami, Oct 23, 2009, http://jimboguy.blogspot.com

Obama vs. FOX

http://www.zcommunications.org/znet/viewArticle/22930

... Frank Schaeffer is the author of Crazy for God: How I Grew Up as One of the Elect, Helped Found the Religious Right, and Lived to Take All (or Almost All) of It Back and the forthcoming Patience With God: Faith For People Who Don't Like Religion (Or Atheism). ...

President Obama is getting criticism for going after Fox News. I fault the White House too: for not going far enough. The real issue is not Fox's right wing "bias." The real issue is that FOX News seems to be trawling for assassins. Here's the letter White House Press Secretary Robert Gibbs should write. Or maybe it should come from the head of United States Secret Service.

Dear Rupert Murdoch, since you are responsible for what is on Fox News I have a question for you: Do you ever wonder how you'll be remembered by Americans and the world (not to mention your children) if someone takes a shot at President Obama, and when asked why they did it, quotes the misinformation spouted by Fox News as their "reason?"

You have dozens of far right and dangerous and/or crazy seeming commentators working for you but let's just talk about one as an example of the rest. What of Glenn Beck?

Does the name Father Charles Coughlin ring a bell? Do you want to be remembered as the facilitator of today's version of that deranged radio personality and hater who hounded President Roosevelt? What if a Coughlin devotee had assassinated Roosevelt? Instead of just being a nasty footnote to American history, Coughlin would be remembered as another John Wilkes Booth. What if Coughlin had had someone with money and virtually unlimited influence backing him and amplifying his remarks? How would we feel about his backer?

Glenn Beck is a second rate, not terribly bright Coughlin-type demagogue with rather dimwitted followers. And you are the paymaster making his silliness dangerous by giving him a voice that would otherwise be heard only by those who happened to hear him barking at the moon on some lonely street corner.

You've given today's Coughlins -- the haters -- a national platform. And they have taken the lies of the "birthers", "deathers", "Obama-is-the-Antichristers" etc., nationwide. It was a bad day for America when you became a citizen for the sole purpose of purchasing TV stations and invading us with your far right agenda. But you've gone way past politics, even the politics of hate. You have legitimized actual insanity by widespread repetition of extremist racist and religion-based lies to the sort of people who believe the earth is 6000 years old, that Jesus will come back soon and send everyone not like them to Hell, that Obama is the Antichrist. In other words, you've got the keys to the national asylum, are stirring up the inmates and threatening to unlock the door!

Here's a sample (compiled with the help of Media Matters and the online magazine Crooks and Liars) of just a small stock of the incendiary rhetoric and bare-faced lies your money pays for.

Fox News host Glenn Beck has:

# said President Obama has, "a deep-seated hatred for white people or the white culture,"

# flirted with the idea that FEMA is building detention camps,

# suggested that President Obama is purposefully "tanking" the economy to force young people to work for AmeriCorps, ...

You can't claim you're not having a baleful impact. How about this? According to the Boston Globe ("Secret Service Strained" October 18, 09),

"The unprecedented number of death threats against President Obama, a rise in racist hate groups, and a new wave of antigovernment fervor threaten to overwhelm the US Secret Service, according to government officials and reports, raising new questions about the 144-year-old agency's overall mission." ...

Wednesday, June 17, 2009

Scientific Discoveries Extending Human Lifespan

CONTENTS:

Achievetrons

Deacetylation of Telomers Crucial to Longevity in Humans

Protein Regulating Movement of Mitochondria Keeps Oxygen in Neurons from Oxygen Cutoff

Epigenetics: 100 Reasons To Change The Way We Think About Genetics

Mutations of Live Attenuated TB Vaccine Believed to Cause It to Lose Its Effectiveness

New Study Genetic Study Shows Humans and Mice Have Only Four Fifths of Common Genes Explaining Failures of Treatments Working on Mice, but Not on Humans

The Good Guide to Health

Women Better Off Choosing Unattractive Males for Mates to Increase Chances for Successful Son


Melting Ice Sheets May Threaten Northeast USA and Canada

Depleted Water Tables Induce Droughts as Experienced in Northern China and India

__________________________________________________________________________________

Achievetrons

Lewis H. Lapham is the National Correspondent for Harper’s Magazine and the editor of Lapham’s Quarterly. http://harpers.org/archive/2009/03/0082408

Few men are so disinterested as to prefer to live in discomfort under a government which they hold to be right, rather than in comfort under one which they hold to be wrong.

Wedgwood

... The courses of undergraduate instruction at our prestigious colleges and universities no longer encourage or reward the freedoms of mind likely to disturb the country’s social and political seating plan. During the early years of the twentieth century, before America fell a foul of the dream of empire, the students on the lawns of academe, most of them inheritors of wealth and social position, already were assured of their getting ahead in the world. They could afford to take chances, to read or not to read the next day’s letter from Virginia Woolf or Julius Caesar, to mess up the protocols of political correctness, worship false gods, maybe go to Paris to try their luck with absinthe, their hand and eye at modern art or ancient decadence. If they strayed into the wilderness of politics, they did so in the manner of both Theodore and Franklin Roosevelt, with the enthusiasm of the amateur explorer. ... http://harpers.org/archive/2009/03/0082408

_______________________________________________________________________________

(I have hope for President Obama because Columbia University requires reading the classics to understand the foibles of man, and the only one of the Ivy League schools to require such classes. Barbara Tuchman’s “The March of Folly: From Troy to Vietnam” shows that leaders, even those who head the Church, can be stupid, vain, and corrupt all at once. Since President Obama occupies the middle politically while talking left, but acting as a centrist, I have had difficulty predicting where he will fall on any particular program or policy. As you may have surmised, I don’t live in awe of the Best and the Brightest because I have seen the Clay Feet of many I have seen and experienced as a chemist in both an Academic environment and in industrial research, and my considering reading about politicians who came from the Best Schools. I love Lapham because he is from that Class, but sees the clay feet of those who run our government, financial system and unfortunately our lives. You can scroll through the various topics below and read what you might enjoy and learn. Jim)

President Barack Obama’s Christmas shopping for cabinet officers in December of last year prompted the national news media to rejoice in the glad tiding that his campaign slogan, “Change you can believe in,” was just and only that, a slogan. Instead of showing himself partial to “closet radicals” who might pose some sort of deep downfield threat to the status quo, Obama was choosing wisely from the high-end, happy few, dispensing with “the romantic and failed notion” that individuals never before seen on the White House lawn could provide the “maturity” needed “in a time of war and economic crisis.” David Brooks assured his readers in the New York Times that the incoming apparat, its members “twice as smart as the poor reporters who have to cover them,” embodied “the best of the Washington insiders.” “Achievetrons . . . who got double 800s on their SATs,” said Brooks, taking pains to list the schools from which they had received diplomas (Columbia, Harvard, Wellesley, Harvard Law, Stanford, Yale Law, Princeton, etc.) attesting to the worth of their wise counsel.

Karl Rove, former advance man for President George W. Bush, informed the Wall Street Journal that Tim Geithner (Dartmouth, Johns Hopkins) as secretary of the Treasury and Larry Summers (M.I.T., Harvard) as director of the National Economic Council were “solid picks,” both investments rated “reassuring” and “market-oriented.” ... Barack Obama’s Christmas shopping for cabinet officers in December of last year prompted the national news media to rejoice in the glad tiding that his campaign slogan, “Change you can believe in,” was just and only that, a slogan. Instead of showing himself partial to “closet radicals” who might pose some sort of deep downfield threat to the status quo, Obama was choosing wisely from the high-end, happy few, dispensing with “the romantic and failed notion” that individuals never before seen on the White House lawn could provide the “maturity” needed “in a time of war and economic crisis.” David Brooks assured his readers in the New York Times that the incoming apparat, its members “twice as smart as the poor reporters who have to cover them,” embodied “the best of the Washington insiders.” “Achievetrons . . . who got double 800s on their SATs,” said Brooks, taking pains to list the schools from which they had received diplomas (Columbia, Harvard, Wellesley, Harvard Law, Stanford, Yale Law, Princeton, etc.) attesting to the worth of their wise counsel. Karl Rove, former advance man for President George W. Bush, informed the Wall Street Journal that Tim Geithner (Dartmouth, Johns Hopkins) as secretary of the Treasury and Larry Summers (M.I.T., Harvard) as director of the National Economic Council were “solid picks,” both investments rated “reassuring” and “market-oriented.”

The mood was not as festive in the workshops of the romantic left, but even the churls who thought the appointees insufficiently progressive in their views of the American future took comfort in the remembrance of their candidate saying somewhere in a post-election speech, “Understand where the vision for change comes from. First and foremost, it comes from me.”

David Corn, the Washington bureau chief for Mother Jones, told the Washington Post that although the hotheads among his acquaintance were “disappointed, irritated or fit to be tied,” they held fast to the belief that Obama (Columbia, Harvard Law) would set the agenda, reprogram the operatives complicit in the stupidity and cynicism of the Bush and Clinton administrations; pragmatism was the watchword, and the dawning of a bright new day was guaranteed by the installation of what Brooks proclaimed a “valedictocracy,” post-partisan and non-ideological, its shoes shined, its hair combed, its ambition neatly pressed.

The recommendation deserves to be ranked with the ones until recently in vogue at the Palm Beach Country Club among the members acquainted with the achievetron Bernie Madoff. For the past sixty years the deputies assigned to engineer the domestic and foreign policies of governments newly arriving in Washington have come outfitted with similar qualifications— first-class schools, state-of-the-art networking, apprenticeship in a legislative body or a think tank—and for sixty years they have managed to weaken rather than strengthen the American democracy, ending their terms of office as objects of ridicule if not under threat of criminal arrest.

The Harvard wunderkinds (a.k.a. “the best and the brightest”) who followed President John F. Kennedy into the White House in 1961 hung around the map tables long enough to point the country in the direction of the Vietnam War. Henry Kissinger, another Harvard prodigy, imparted to American statecraft the modus operandi of a Mafia cartel. The Reagan Administration imported its book of revelation from the University of Chicago’s School of Economics (“privatization” the watchword, “unfettered free market” the Christian name for Zeus) and by so doing set in motion what lately has come to be seen as a long- running Ponzi scheme. Take into account the Ivy League’s contributions to the Bush Administration—Attorney General John Ashcroft (Yale), Secretary of Defense Donald Rumsfeld (Princeton), director of Homeland Security Michael Chertoff (Harvard)—and I can imagine a doctoral thesis commissioned by the Kennedy School of Government and meant to determine which of the country’s leading institutions of higher learning over the past fifty years has done the most damage to the health and happiness of the American people.

It’s conceivable that the Obama Administration will prove itself the exception to the rule, but when the president says that his vision for change “comes from me” he leaves open the question as to whether he intends to generate itex cathedra (Barter) or ex nihilo (Out of Nothing ) . Neither method offers much chance of success if what is wanted or required is a recasting of the American democracy on a scale comparable to Franklin Roosevelt’s New Deal. Socioeconomic alterations of a magnitude sufficient to be recognized as such tend to be collective enterprises, usually brought about by powers of mind and forces of circumstance outside, not inside, the circle of A-list opinion—the barbarians at the gates of fifth-century Rome, the sixteenth-century Protestant Reformation _personae non gratae _at the Vatican, the authors of the American Constitution far removed from the certain truths seated on velvet cushions in eighteenth-century London. Ulysses S. Grant, perhaps Lincoln’s most effective general, was virtually unknown to the War Office in Washington before the bombardment of Fort Sumter; during the Great Depression of the 1930s, FDR composed a “Brain Trust” of individuals (some of them academics, others not, none of them rounded up from the quorum of usual suspects) as willing as the president to “take a method and try it; if it fails, admit it frankly, and try another.” http://harpers.org/archive/2009/03/0082408

Deacetylation of Telomers Crucial to Longevity in Humans ... Scientists have long known that a class of proteins called sirtuins promotes fitness and longevity in most organisms ranging from single-celled yeast to mammals. At the cellular level, sirtuins protect genome integrity, enhance resistance to adverse stresses, and antagonize senescence. However, the underlying molecular mechanisms have remained poorly understood.

The team, led by senior author Shelley Berger, Ph.D., Hilary Koprowski Professor at The Wistar Institute, demonstrated for the first time a molecular target for a member of this class, Sir2, in regulation of aging in yeast cells. Sir2 removes an acetyl group attached to a specific site (lysine at position 16 or K16) on histone H4—histones are proteins that package and organize the long strands of DNA within the nucleus and also are central regulators in turning genes on and off. The study reveals that removal of this acetyl group by Sir2 near the chromosome ends—the telomeres—is important for yeast cells to maintain the ability to replicate. Researchers found that Sir2 levels decline as cells age, and there is a concomitant accumulation of the acetylation mark along with disrupted histone organization at telomeres.

Deacetylation of H4K16 by Sir2 and consequent telomere stability play a major role in maintaining long lifespan in yeast. Since sirtuins deacetylate many different proteins, these results clarify a key role of Sir2 protein in control of lifespan.

"Some modifications on histones, like this acetylation on histone H4 lysine 16, are persistent and are maintained through generations of cell divisions. This DNA-independent inheritance is called epigenetics," Berger says. "Characteristic epigenetic features have been discovered for various developmental processes in recent years. Understanding epigenetic changes associated with aging is a hugely exciting direction in aging research. It will provide insights and ideas not only for new therapies to regulate cells that have lost control of proliferation, such as 'immortal' cells found in cancers, but also for new strategies to maintain health and fitness." ... http://www.sciencedaily.com/releases/2009/06/090610133447.htm


Protein Regulating Movement of Mitochondria Keeps Oxygen in Neurons from Oxygen Cutoff

... Understanding the mechanisms that regulate the movement of mitochondria may help scientists identify how the brain's cells ward off and potentially repair damage. An example is the role that mitochondria play as a calcium buffer. One of the mitochondria's functions is to help control the concentration of calcium in the cell, which the organelles can rapidly absorb and store. This capacity is important, particularly in instances when calcium levels in the cell spike during a stroke, a condition which contributes a cascading series of events that ultimately lead to a state called excitotoxicity and cell death.

One of the keys to identifying the function of HUMMR has been the appreciation in that the body operates at a relatively low oxygen level. While the air we breath consists of approximately 20% oxygen, the cells in the brain sit at somewhere between 2-5% oxygen. This creates a "normal" state of hypoxia in the brain.

However, the concentration of oxygen in the brain can drop even further in instances such as a stroke, when blood flow to a portion of the brain is cut off. This decrease in oxygen promotes the expression of HUMMR which, in turn, mobilizes mitochondria. More mitochondria in the correct position may mean the cell has a greater capacity to filter out toxic levels of calcium. Rempe and his colleagues are now investigating the role that HUMMR may play in stroke models, particularly whether or not this activity helps protect vulnerable cells that lie just outside the core areas of the brain that are damaged by stroke. ... http://www.sciencedaily.com/releases/2009/06/090615093925.htm


Epigenetics: 100 Reasons To Change The Way We Think About Genetics

ScienceDaily (May 20, 2009) — For years, genes have been considered the one and only way biological traits could be passed down through generations of organisms.


Not anymore.

Increasingly, biologists are finding that non-genetic variation acquired during the life of an organism can sometimes be passed on to offspring—a phenomenon known as epigenetic inheritance. An article forthcoming in the July issue of The Quarterly Review of Biology lists over 100 well-documented cases of epigenetic inheritance between generations of organisms, and suggests that non-DNA inheritance happens much more often than scientists previously thought.

Biologists have suspected for years that some kind of epigenetic inheritance occurs at the cellular level. The different kinds of cells in our bodies provide an example. Skin cells and brain cells have different forms and functions, despite having exactly the same DNA. There must be mechanisms—other than DNA—that make sure skin cells stay skin cells when they divide.

Only recently, however, have researchers begun to find molecular evidence of non-DNA inheritance between organisms as well as between cells. The main question now is: How often does it happen?

"The analysis of these data shows that epigenetic inheritance is ubiquitous …," write Eva Jablonka and Gal Raz, both of Tel-Aviv University in Israel. Their article outlines inherited epigenetic variation in bacteria, protists, fungi, plants, and animals.

These findings "represent the tip of a very large iceberg," the authors say.

For example, Jablonka and Raz cite a study finding that when fruit flies are exposed to certain chemicals, at least 13 generations of their descendants are born with bristly outgrowths on their eyes. Another study found that exposing a pregnant rat to a chemical that alters reproductive hormones leads to generations of sick offspring. Yet another study shows higher rates of heart disease and diabetes in the children and grandchildren of people who were malnourished in adolescence.

In these cases, as well as the rest of the cases Jablonka and Raz cite, the source of the variation in subsequent generations was not DNA. Rather, the new traits were carried on through epigenetic means.

There are four known mechanisms for epigenetic inheritance. According to Jablonka and Raz, the best understood of these is "DNA methylation." Methyls, small chemical groups within cells, latch on to certain areas along the DNA strand. The methyls serve as a kind of switch that renders genes active or inactive.

By turning genes on and off, methyls can have a profound impact on the form and function of cells and organisms, without changing the underlying DNA. If the normal pattern of methyls is altered—by a chemical agent, for example—that new pattern can be passed to future generations.

The result, as in the case of the pregnant rats, can be dramatic and stick around for generations, despite the fact that underlying DNA remains unchanged. ... http://www.sciencedaily.com /releases/2009/05/090518111723.htm

Mutations of Live Attenuated TB Vaccine Believed to Cause It to Lose Its Effectiveness ScienceDaily (May 24, 2009) —

Not fully realized by researchers about how attenuated vaccines can mutate back to the more virulent ones as seen in the polio vaccine in India due to excretion of the modified virus into to the water supply. Viruses mutate by breaking up and recombining with fragments of other viruses. In this way they might be able to change the attenuated vaccine back to the more virulent one. So I question whether some of the weakness of vaccines could be due to the introduction of more more virulent or less effective species.

In this case the TB bacteria vaccine became less effective because it still produced antioxidants because our immune response works by an oxidation process. When the researcher first author Lakshmi Sadagopal, Ph.D., research instructor of Medicine proposed this approach, many negative responses occurred, but she was able to convince Professor Kermodle.

One good result of all the smart students going into higher income areas such as finance is that it left room for the so-called lesser students such as women and foreigners to make many of the recent breakthroughs in research such as Lakshmi Sadagopal. Bill & Melinda Gates looked into the future effects of global warming where migration of both people and bugs will bring diseases to the Developed Countries. So they have heavily funded research in Malaria and AIDs and Drug development neglected by Big Pharma to prepare us for our certain future.


Jim Kawakami

May 24, 2009

The Aeras Global TB Vaccine Foundation, supported by the Bill & Melinda Gates Foundation, has already licensed the modification technology developed by Kernodle and colleagues. Aeras is working to make the best possible modified BCG vaccine, and it has built the infrastructure to conduct clinical trials in South Africa, Kenya and India – countries with a high incidence of TB. ...

A team of Vanderbilt University Medical Center investigators has cracked one of clinical medicine's enduring mysteries – what happened to the tuberculosis vaccine. The once-effective vaccine no longer prevents the bacterial lung infection that kills more than 1.7 million people worldwide each year. ...

The current TB vaccine, known as BCG (bacille Calmette-Guérin), has been around since the 1920s. It was made by weakening (attenuating) a strain of bacteria that causes tuberculosis in cows and that genetically is 98 percent identical to the human TB germ. ...

Kernodle and colleagues came to the problem of BCG's poor activity against pulmonary TB from a different angle. They had reported in 2001 that one way TB itself evades the immune system is by producing antioxidants. Since BCG also produces antioxidants, they suggested that removing BCG's antioxidant-producing capacity might improve the vaccine.

"Our idea to take something away from BCG – and therefore theoretically attenuate it even further – was met with a lot of skepticism," Kernodle said. "But we believed our data that we could make BCG more immunogenic and safer." ...

In the current studies, first author Lakshmi Sadagopal, Ph.D., research instructor of Medicine, vaccinated mice with a modified BCG (genetically changed in three ways to reduce or eliminate the production of several antioxidants) and examined the immune response in the days following vaccination and later with a "challenge" dose of BCG.

She found that, compared to BCG, the modified BCG induced greater cytokine (immune regulatory factor) production during the early phase of the immune response, more CD8 cell-killing T cells at the peak of the primary response, and more CD4 helper T cells during the memory phase. Modified BCG also produced greater recall immune responses and was eliminated better by the vaccinated host animal than the parent BCG vaccine, which might correlate with improved safety in humans.

"At each time point of the immune response, the modified BCG vaccine worked better than the parent BCG vaccine," Kernodle said. "By targeting antioxidants that had increased in expression during decades of cultivation, we ended up making BCG more like it was back in the 1920s when it was 80 percent effective against pulmonary TB. We fixed it."

Using modern molecular techniques to reduce the activity of antioxidants below levels in naturally occurring strains, "it should be possible to make it even better than the original BCG," he added. ... http://www.sciencedaily.com/releases/2009/05/090519152446.htm

New Study Genetic Study Shows Humans and Mice Have Only Four Fifths of Common Genes Explaining Failures of Treatments Working on Mice, but Not on Humans

ScienceDaily (May 27, 2009) — A new article in PLoS Biology explores exactly what distinguishes the human genome from that of the lab mouse. In the first comprehensive comparison between the genes of mice and humans, scientists from institutions across America, Sweden and the UK reveal that there are more genetic differences between the two species than had been previously thought.


One-fifth of mouse genes are new copies that have emerged in the last 90 million years of mouse evolution. These large differences between genes in humans and the mouse are likely to reflect many of the differences that distinguish human and mouse biology.

These findings are reported in a landmark publication describing the finished genome sequence of the mouse, which, after the human, is only the second completed sequence for any mammal. That humans and mice have four-fifths of their genes in common – and that these genes have been identified - directly enhances scientists' abilities to pick out mouse genes that are most applicable to human disease. In effect, what this new research has shown is how to neatly separate biology that humans share with mice from biology found in one species only. ... http://www.sciencedaily.com /releases/2009/05/090526202722.htm

The Good Guide to Health

By CLAIRE CAIN MILLER

Published: June 14, 2009

SAN FRANCISCO — These days, every skin lotion and dish detergent on store shelves gloats about how green it is. How do shoppers know which are good for them and good for the earth?He realized he did not know what was in the lotion. He went to his office and quickly discovered that it contained a carcinogen activated by sunlight. It also contained an endocrine disruptor and two skin irritants. He also discovered that her soap included a kind of dioxane, a carcinogen, and then found that one of her brand-name toys was made with lead.

And in looking for the answer, he hatched the idea for a company that used his esoteric research on supply chain management. “All I do is study this, and I know nothing about the products I’m bringing into our house and putting in, on and around our family,” Mr. O’Rourke said. But when he wanted to find that information, he could. Most consumers would struggle to do so.

Hence GoodGuide, a Web site and iPhone application that lets consumers dig past the package’s marketing spiel by entering a product’s name and discovering its health, environmental and social impacts. ... http://www.nytimes.com/2009/06/15/technology/internet/15guide.html?em

Women Better Off Choosing Unattractive Males for Mates to Increase Chances for Successful Son



(I am unusually attracted to actress types according to Jung. Unfortunately I found them to be unsuitable marriage material. But I did notice many of the men who go into acting are Gay or of undetermined sexuality at UCLA. Anyone have a different opinion? Jim)


... In a research paper published in the Oct. 7 edition of the prestigious journal Science, UBC zoology professor Sarah Otto and graduate student Arianne Albert propose a model that explains why males in some species have extravagant displays for attracting females, while males in other species look just like females.

Many groups of animals, including humans, have an “XY” sex-determining system through which the father determines the sex of the offspring -- the offspring is female if it receives an X chromosome from the father, and vice versa. For these species, the chromosome on which flashy displays is coded will determine whether the sons or the daughters inherit the physical trait.

“If the genes coding for flashy displays are on the X, the genes from a sexy dad only appear in his daughters, making them visible to predators without improving their reproductive success, and thus favouring the evolution of preferences for dull males,” says Albert, lead author of the paper. ... http://www.sciencedaily.com/releases/2005/10/051009201943.htm


Money Worries Make Women Spend More

ScienceDaily (May 23, 2009) — At times of crisis women are more inclined to spend themselves out of misery than at stable times, a new survey suggests. Psychologists say that the recession could force more women to overspend or increase their risk of mental illness.


A survey conducted by Professor Karen Pine, from the University of Hertfordshire and author of Sheconomics, to be released on 21 May 2009 found that 79% of women said they would go on a spending spree to cheer themselves up. Professor Pine’s research concludes that some women use shopping as an emotion regulator, a way of anesthetising themselves to negative feelings or dissatisfaction with life. So worrying about money could, paradoxically, lead women to spend more.

Of the 700 women surveyed, four out of ten named ‘depression’, and six out of ten named ‘feeling a bit low’, as reasons to go on a spending spree and overspend. Women commonly expressed the view that shopping has the power to make them feel better.

Professor Pine’s research found that an intense emotional state, high or low, could send women to the shops. “This type of spending, or compensatory consumption, serves as a way of regulating intense emotions,” she said.

This ability to regulate emotions is crucial for mental and physical wellbeing and humans adopt a variety of means of doing so, including drugs and alcohol. Shopping is one method increasingly adopted by women.

“If shopping is an emotional habit for women they may feel the need to keep spending despite the economic downturn,” said Professor Pine. “Or, perhaps worse still, if they can’t spend we might see an increase in mental health problems such as anxiety and depression.” ... http://www.sciencedaily.com/releases/2009/05/090521084834.htm

Melting Ice Sheets May Threaten Northeast USA and Canada


This visualization, based on new computer modeling, shows that sea level rise may be an additional 10 centimeters (4 inches) higher by populated areas in northeastern North America than previously thought. Extreme northeastern North America and Greenland may experience even higher sea level rise. (Credit: Graphic courtesy Geophysical Research Letters, modified by UCAR)

ScienceDaily (May 28, 2009) — Melting of the Greenland ice sheet this century may drive more water than previously thought toward the already threatened coastlines of New York, Boston, Halifax, and other cities in the northeastern United States and Canada, according to new research led by the National Center for Atmospheric Research (NCAR).


The study, which is being published May 29 in Geophysical Research Letters, finds that if Greenland's ice melts at moderate to high rates, ocean circulation by 2100 may shift and cause sea levels off the northeast coast of North America to rise by about 12 to 20 inches (about 30 to 50 centimeters) more than in other coastal areas. The research builds on recent reports that have found that sea level rise associated with global warming could adversely affect North America, and its findings suggest that the situation is more threatening than previously believed.

"If the Greenland melt continues to accelerate, we could see significant impacts this century on the northeast U.S. coast from the resulting sea level rise," says NCAR scientist Aixue Hu, the lead author. "Major northeastern cities are directly in the path of the greatest rise."

A study in Nature Geoscience in March warned that warmer water temperatures could shift ocean currents in a way that would raise sea levels off the Northeast by about 8 inches (20 cm) more than the average global sea level rise. But it did not include the additional impact of Greenland's ice, which at moderate to high melt rates would further accelerate changes in ocean circulation and drive an additional 4 to 12 inches (about 10 to 30 cm) of water toward heavily populated areas of northeastern North America on top of average global sea level rise. More remote areas in extreme northeastern Canada and Greenland could see even higher sea level rise.

Scientists have been cautious about estimating average sea level rise this century in part because of complex processes within ice sheets. The 2007 assessment of the Intergovernmental Panel on Climate Change projected that sea levels worldwide could rise by an average of 7 to 23 inches (18 to 59 cm) this century, but many researchers believe the rise will be greater because of dynamic factors in ice sheets that appear to have accelerated the melting rate in recent years.

The new research was funded by the U.S. Department of Energy and by NCAR's sponsor, the National Science Foundation. It was conducted by scientists at NCAR, the University of Colorado at Boulder, and Florida State University. ... http://www.sciencedaily.com /releases/2009/05/090527121055.htm

Depleted Water Tables Induce Droughts as Experienced in Northern China and India

The Amazon Rain Forest water evaporation from trees produces its own source of heavy rains. So since we are depleting many of the water tables in Texas, Colorado, and Montana, it is likely future droughts will become more severe. Northern China went from green fields to expanding desert sands by depleting their water tables by excessive farming. The frequent dust storms in Beijing are something to dread for visitors as well as residents near these northern desert regions.

Jim Kawakami

June 4, 2009

ScienceDaily (Oct. 1, 2008) — Will there be another "dust bowl" in the Great Plains similar to the one that swept the region in the 1930s?


It depends on water storage underground. Groundwater depth has a significant effect on whether the Great Plains will have a drought or bountiful year.

Recent modeling results show that the depth of the water table, which results from lateral water flow at the surface and subsurface, determines the relative susceptibility of regions to changes in temperature and precipitation.

"Groundwater is critical to understand the processes of recharge and drought in a changing climate," said Reed Maxwell, an atmospheric scientist at Lawrence Livermore National Laboratory, who along with a colleague at Bonn University analyzed the models that appear in the Sept. 28 edition of the journal Nature Geoscience.

Maxwell and Stefan Kollet studied the response of a watershed in the southern Great Plains in Oklahoma using a groundwater/surface-water/land-surface model.

The southern Great Plains are an important agricultural region that has experienced severe droughts during the past century including the "dust bowl" of the 1930s. This area is characterized by little winter snowpack, rolling terrain and seasonal precipitation.

While the onset of droughts in the region may depend on sea surface temperature, the length and depth of major droughts appear to depend on soil moisture conditions and land-atmosphere interactions. ...

The models showed that groundwater storage acts as a moderator of watershed response and climate feedbacks. In areas with a shallow water table, changes in land conditions, such as how wet or dry the soil is and how much water is available for plant function, are related to an increase in atmospheric temperatures. In areas with deep water tables, changes at the land surface are directly related to amount of precipitation and plant type.

But in the critical zone, identified here between two and five meter's depth, there is a very strong correlation between the water table depth and the land surface.

"These findings also have strong implications for drought and show a strong dependence on areas of convergent flow and water table depth," Maxwell said. "The role of lateral subsurface flow should not be ignored in climate-change simulations and drought analysis." ... http://www.sciencedaily.com/releases/2008/09/080929133725.htm