Monday, November 15, 2010

Vitamin D Experts “Opinions” Sepsis Obesity Cancer Heart Bone Colds Profits

Tags: Vitamin D Profits Big Pharma or People Experts “Opinions” Sepsis Obesity Cancer Heart Bone Colds Autoimmune Diseases

In recent years the actual reason why vitamin D hormone in active form helps us prevent so many diseases and the lack of causes so many is that it activates our T-Cells which stop infections of all kinds including cancers at earlier stages. At late states cancers develop a resistance to vitamin D, possibly because of its mass. It works by sending in T-Cells and preventing the formation of new blood vessels to support cancer growth.

It fixes our immune system so autoimmune diseases are also ameliorated if not fixed as in my case so our immune system does not attack our own cells including nerve cells.

For years we have seen those medical researchers and doctors connected to Big Pharma push sunscreen use even though evidence for their harm existed shortly after they introduced UVB sunscreens with a mushrooming of melanoma in both Australia and Sweden in the 1980s. Note in the article that the blood levels of 25-hydroxy-Vitamin D are not given before and after given vitamin D.

Autism cases doubled in California in the 1990s, chiefly among the affluent who tend to believe official pronouncements.

Unfortunately more common sense Americans don’t read and do not have the knowledge to make decisions either. See “Trust Us We’re Experts” a marvelous book about how newspapers, television, and books propagandize the elites. Yes, our CIA writes many books and even magazines such as The Reporter justifying the Vietnam War.

Here are articles on both sides of the Vitamin D issues.

Jim Kawakami, Nov 15, 2010, http://jimboguy.blogspot.com

Kawakami: Another suspect study of three months whether vitamin D helps osteoarthritis is also in the same vane where they concluded that it does not help. http://www.webmd.com/osteoarthritis/news/20101108/vitamin-d-fails-osteoarthritis-test

Unfortunately one needs to sometimes go outside the USA to get less biased information. Here is an excerpt:

… The combination of vitamin D and calcium has long been recommended to reduce the risk of bone fracture for older people, particularly those at risk of or suffering from osteoporosis, which is estimated to affect about 75m people in Europe, USA and Japan.

The action of the nutrients is complimentary, with calcium supporting bone formation and repair, while vitamin D helps the body absorb calcium.

Indeed, the European Food Safety Authority (EFSA) accepted a health claim linking calcium and vitamin D to bone health in older women in 2008 following a disease-reduction claim application, made under article 14 of the European Union’s nutrition and health claims regulation and submitted by Abtei Pharma Vertriebs, a GlaxoSmithKline company. … http://www.nutraingredients.com/Research/Calcium-plus-vit-D-effective-for-bone-density-boost-Study

Researchers combing a large database have found evidence to suggest that vitamin D levels play a highly significant role in cardiovascular health, according to an article published in the Oct. 1 issue of the American Journal of Cardiology.


Vitamin D Plays a Highly Significant Role in Cardiovascular Health http://www.doctorslounge.com/index.php/news/pb/15598 FRIDAY, Nov. 12 (HealthDay News) -- Researchers combing a large database have found evidence to suggest that vitamin D levels play a highly significant role in cardiovascular health, according to an article published in the Oct. 1 issue of the American Journal of Cardiology.


Jeffrey L. Anderson, M.D., of the Intermountain Medical Center in Murray, Utah, and colleagues analyzed 41,504 patient records with at least one measured vitamin D level to determine the prevalence of vitamin D deficiency and how that relates to cardiovascular risk factors, disease, and mortality.


The researchers found a 63.6 percent prevalence of vitamin D deficiency, which was associated with highly significant increases in diabetes, hypertension, hyperlipidemia, and peripheral vascular disease. Levels of vitamin D were also found to be strongly associated with coronary artery disease, myocardial infarction, heart failure, stroke, and mortality.


"In conclusion, we have confirmed a high prevalence of vitamin D deficiency in the general health care population and an association between vitamin D levels and prevalent and incident cardiovascular risk factors and outcomes. These observations lend strong support to the hypothesis that vitamin D might play a primary role in cardiovascular risk factors and disease. Given the ease of vitamin D measurement and replacement, prospective studies of vitamin D supplementation to prevent and treat cardiovascular disease are urgently needed," the authors write.


Those who sell vitamin D3 also push the health benefits:

BASF is a leading supplier of vitamin D 3 . The vitamin does more than regulate the body’s calcium household, which already makes it essential for bone growth and stability. In fact, it has turned out that its beneficial effects on health are more extensive and had long been underestimated.

Vitamin D 3 has now been recognized as being important for lowering the risk of health problems as diverse as cardiovascular maladies, various types of cancer (such as colon and breast cancer), diabetes, and inflammatory diseases such as asthma.

Although it is made by the body (With UVB, burning rays, which sunscreens block, so even those living in sunny Miami have vitamin D deficiency Jim), in contrast to other vitamins, many people do not have an adequate vitamin D3 status. Individuals of all age groups are afflicted throughout the world. To remedy this deficit and meet the growing need, vitamin D 3 -enriched foods and food supplements may play an important role in the future. Health authorities are now studying whether the recommended minimum daily intake of vitamin D 3 should be raised.

BASF supplies very high-quality vitamin D3 in oil-based formulations and powders that are nonallergenic, gluten-free, kosher-, and halal-certified. … http://www.webwire.com/ViewPressRel.asp?aId=126642

Here is one trying to keep recommended vitamin D levels very low.

Monrovia, CA (PRWEB) November 14, 2010

http://www.sfgate.com/cgi-bin/article.cgi?f=/g/a/2010/11/14/prweb4784874.DTL At last year's meeting of the Codex Committee on Nutrition and Foods for Special Dietary Uses (CCNFSDU) in Dusseldorf, Germany, the National Health Federation (with help from the Indian and Iraqi delegations) was able to stop the advance of those Guidelines on Nutrient Reference Values (NRVs) that would have set low numerical values for vitamins and minerals. Some delegations, especially Australia, were strongly pushing for these "dumbed down" NRVs to go forward. Had they gone forward at that time - as they very nearly did - then we would now be looking at well-advanced Codex NRVs of, for example, 45 milligrams for Vitamin C and 200 IUs for Vitamin D as providing 100% of an adult's daily nutritional needs. …

Read more: http://www.sfgate.com/cgi-bin/article.cgi?f=/g/a/2010/11/14/prweb4784874.DTL#ixzz15O5GZIHJ


Could Lack of Vitamin D Deficiency Explain Sepsis Risk in Elderly Patients? Journal of the American Medical Association or JAMA, Oct 27, 2010

http://www.foodconsumer.org/newsite/Nutrition/Vitamins/itamin_d_deficiency_explain_sepsis_2710100641.html

Older patients with sepsis who were critically ill and hospitalized were more likely to experience severe cognitive impairment and abnormal physical decline years later, according to a recent study published in the Oct 27, 2010 issue of the Journal of the American Medical Association.

In response to the study, a health observer suggested that vitamin D deficiency may be at least partially responsible for sepsis and the worsened mental and physical decline in the patients hospitalized and treated for sepsis.

This case-control study led by Theodore J. Iwashyna, M.D., Ph.D., and colleagues at the University of Michigan was to compare the cognitive decline and physical limitations in patients hospitalized for sepsis and those without sepsis.

The study involved 516 people who survived 623 hospitalizations for severe sepsis between 1998 and 2006. The average age for hospitalization due to sepsis was 77.

The study shows that among those who were hospitalized for sepsis, 60 percent experienced worsened cognitive or physical function or both and sepsis patients who survived sepsis after hospitalization were 3.33 times more likely to worsen their mental status to moderate or severe cognitive impairment years later compared to the risk before hospitalization.

The study also found sepsis survivors who had no limitation before sepsis developed an average 1.57 new functional limitations. This is compared to 0.48 new functional limitations developed after hospitalization in patients without sepsis.

Hospitalization for non-sepsis conditions was not associated with elevated risk of cognitive decline and development of functional limitations.

The researchers estimated sepsis may be responsible for 20,000 new cases of dementia among people aged 65 years or older each year in the United States.

The study demonstrated that sepsis survivors face risk of severe cognitive decline and physical limitations years later. But it did not prove sepsis caused the worsening of cognitive function and physical limitations although it seemingly suggests that sepsis may cause the complications.

It could be that the increased risk of worsened mental decline result from medications used for sepsis or some underlying conditions in the hospitalized patients with sepsis.

Sepsis is a bloodstream infection. Young children, elderly people and those who have their immunity compromised are at high risk of sepsis because their immune systems are weakened or under development.

Vitamin D deficiency may be one risk factor for sepsis and its complications. Vitamin D, which is often found low in elderly people, has been associated in many studies with not only a person's vulnerability for infections, but also for cognitive decline.

Llewellyn DJ and colleagues from the University of Exeter in the United Kingdom reported a study in the July 12 2010 issue of Archives of Internal Medicine saying low levels of vitamin D were associated with substantial cognitive decline in the elderly population.

Numerous studies have suggested that Low vitamin D status was associated with a reduced capability for spatial working memory, increased risk of cognitive deficits or cognitive impairment, and dementia, particularly Alzheimer's disease.

Vitamin D deficiency may be a significant part responsible for the increased risk of worsened mental and physical conditions in sepsis patients, the health observer suggested.

Sufficient Vitamin D has been known to boost innate immunity by helping produce antimicrobial peptides, which are protective against infections induced by viruses and bacteria.

As a matter of fact, one study led by Jeng L. and colleagues from Emory University School of Medicine in Atlanta, GA and published in 2009 in Journal of Translational Medicine found that critically ill patients with sepsis had significantly lower plasma D25(OH)D), vitamin D binding protein and cathelicidin - an anti-microbial peptide. The study suggests that vitamin D may be responsible for sepsis.

No study has yet proved that taking vitamin D supplements may help elderly people reduce the risk of sepsis. But Grant W.B., an vitamin D expert suggested in the Feb 2010 issue of Early Human Development that "vitamin D supplementation of mother and infant could reduce risk of sepsis in premature infants." Could this nutrient work as well in elderly people to prevent sepsis?

According to the Centers for Disease Control and Prevention, the rate of hospitalization for sepsis or septicemia for people aged 65 to 74 increased 57 percent from 6.5 per 1,000 to 10.2 and the rate for those aged 75 to 84 increased 52 percent from 11.7 per 1000 to 17.8 during the period between 2000 and 2007.

Elderly people tend to be vitamin D deficient because they stay indoors more often and the production of vitamin D in these individuals is less efficient. Maintaining high levels of this nutrient may help prevent sepsis and dementia among other things.

By Jimmy Downs

Low Vitamin D Not Predictive of Mortality American Heart Association http://www.endocrinetoday.com/view.aspx?rid=77692

Key Excerpts: … According to the study results, there was an approximately 62% increased risk for all-cause mortality from the lowest quartile compared with the highest quartile (HR=1.62; 95% CI, 1.11-2.36), but the relationship did not attain statistical significance when adjusting for confounding variables such as age, ethnicity, hypertension, smoking, CVD, diabetes and others. …

Limitations of the study included potential misclassification of cause-specific mortality, non-random sampling, unmeasured confounding bias and possible misclassification of 25(OH) vitamin D exposure, according to the researchers.

Complete article: “Low vitamin D levels are not an independent prospective risk marker for increased all-cause, CVD or cancer mortality in the WHI,” Charles B. Eaton, MD, of Brown University, said in a presentation. “Waist circumference appears to be an important confounding factor and shows effect modification of the relationship of vitamin D and all-cause mortality.” – by Eric Raible

Researchers for the study enrolled participants in the Women’s Health Initiative (WHI) who were recruited from 40 centers between 1993 and 1998. The analytic cohort included 2,429 postmenopausal women with 25-hydroxyvitamin D levels ascertained in the WHI. Mortality was assessed at annual and semi-annual follow-up, and was collected through a number of methods, including a review of the National Death Index and self-reporting by family members, as well as adjudication of hospitalizations, ED visits, autopsy and coroner’s reports. For the purposes of this study, CVD mortality included coronary disease, cerebrovascular disease, pulmonary embolism, heart failure and other CV causes. Serum 25(OH) vitamin D was assessed using an immunoassay.

Participants were divided into quartiles of seasonal-adjusted vitamin D to account for differences in sun exposure from season to season, with quartile 1 having the lowest levels of vitamin D and quartile 4 having the highest levels.

According to the study results, there was an approximately 62% increased risk for all-cause mortality from the lowest quartile compared with the highest quartile (HR=1.62; 95% CI, 1.11-2.36), but the relationship did not attain statistical significance when adjusting for confounding variables such as age, ethnicity, hypertension, smoking, CVD, diabetes and others (HR=1.27; 95% CI, 0.81-1.99). For CV mortality, the same relationship was observed between the lowest and highest quartiles prior to adjustment (HR=1.92; 95% CI, 1.03-3.58), but also was not statistically significant after adjusting for confounding variables (HR=1.30; 95% CI, 0.83-2.03).

Limitations of the study included potential misclassification of cause-specific mortality, non-random sampling, unmeasured confounding bias and possible misclassification of 25(OH) vitamin D exposure, according to the researchers.

“Low vitamin D levels are not an independent prospective risk marker for increased all-cause, CVD or cancer mortality in the WHI,” Charles B. Eaton, MD, of Brown University, said in a presentation. “Waist circumference appears to be an important confounding factor and shows effect modification of the relationship of vitamin D and all-cause mortality.” – by Eric Raible

No comments:

Post a Comment